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Subjective Effects of Anti-Cholinergic Hallucinogens RALPH METZNER, PH.D

Subjective Effects of Anti-Cholinergic Hallucinogens RALPH METZNER, PH.D

  1. Basoodler
    Study on the use of ditran (deliant chemical weapons) to treat mental illness (interesting read)



    Lysergic acid, tryptamine and phenylethylamine derivatives have received most attention in studies of hallucinogens because of their extraordinary range of effects and their relationship to plants used in certain "primitive,, religions. Other chemicals synthesized in laboratories merit attention because of similarly dramatic effects on consciousness and psychological processes. The series of piperidyl benzilate esters have "psychotomimetic" properties first described by Abood and others (Abood, Ostfeld & Biel 1958). This series, including JB-318, JB-328, and JB-329 (Ditran), lacks the characteristic indole ring or phenylethylamine structure of better-known hallucinogens. The pharmacological activity of the piperidyl benzilate esters appears to be a blocking of acetyl choline, the neural transmitter for the parasympathetic autonomic system. Acetylcholine is also involved at the myoneural junctions (between motor nerves and muscles) and plays an unknown role in the central nervous system. Therefore, these substances produce physiologic effects similar to atropine and scopolamine, prototypical anti-cholinergic compounds