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Successful lung transplantation for talcosis secondary to intravenous abuse of oral drug (2008)

Successful lung transplantation for talcosis secondary to intravenous abuse of oral drug (2008)

  1. testodan
    International Journal of COPD 2008:3(2) 327–330

    Dekel Shlomi, David Shitrit, Daniele Bendayan, Gidon Sahar, Yitshak Shechtman, Mordechai R Kramer

    Talcosis due to intravenous injection of oral drugs can cause severe pulmonary disease with progressive dyspnea even when drug use is discontinued. We describe a 54-yearold woman with severe emphysema who underwent left lung transplantation. The patient had a remote history of intravenous injection of crushed methylphenidate (Ritalin) tablets. Chest
    computed tomography showed severe mphysematous changes, more prominent in the lower lobes. Microscopic examination of the extracted lung demonstrated multinucleated giant cells with birefringent crystals, compatible with talcosis. At follow-up, daily symptoms were completely alleviated and lung function was good. We recommend that lung transplantation be considered as a viable option in the treatment of talcosis.