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Sulfur Analogues of Psychotomimetic Agents. 2. Analogues of (2,5-Dimethoxy-4-methylphenyl)- and (2,5

Sulfur Analogues of Psychotomimetic Agents. 2. Analogues of (2,5-Dimethoxy-4-methylphenyl)- and (2,5

  1. trptamene
    The two thio analogues of each of the well-known psychotomimetic drugs DOM [ (2,5-dimethoxy-4-methylphenyl)
    isopropylamine] and DOET [ (2,5-dimethoxy-4-ethylphenyl)isopropylamineh]a ve been synthesized and
    pharmacologically evaluated in man. The 5-thio isomers are more potent as psychotomimetic agents than the 2-thio
    isomers but still represent a drop of an order of magnitude in potency from the sulfur-free counterparts. The dithio
    analogue of DOM was synthesized and found to be without central activity at a dosage of -50 times the mean effective
    dose of DOM.