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Synthesis of alpha- and beta-amino ketone analogs of amino acids as antibacterial agents

Synthesis of alpha- and beta-amino ketone analogs of amino acids as antibacterial agents

  1. Anonymous
    Volume 51 Issue 2, Pages 108 - 113

    Shu-Sing Cheng, Sigurdur Jonsson, Fred T. Semeniuk

    alpha- and beta-amino ketone analogs of amino acids were synthesized as potential antagonists of amino acids in microbial metabolism. The hypothetical mechanism of antibacterial activity for certain analogs is proposed. The successful use of organo-cadmium reagents for the synthesis of the aliphatic and aromatic series of http://www3.interscience.wiley.com/giflibrary/12/alpha.gif- as well as http://www3.interscience.wiley.com/giflibrary/12/beta.gif-amino ketones indicates a wider scope of applicability than by the method of Dakin-West or by Friedel-Crafts acylation. These series of compounds show antimicrobial activity in vitro.