The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms.

The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms.

  1. ZenobiaSky
    European Journal of Pharmacology 2003 Oct 8; 478 (2-3):155-9.
    Weizman, Pick CG , Backer MM , Rigai T , Bloch M , Schreiber S
    Department of Psychiatry, Tel Aviv Sourasky Medical Center

    Abstract
    Antinociceptive effects of various neuroleptics in animal acute pain-models have been described, mediated trough different pathways including the opioid system. In this study, we assessed the antinociceptive effects of the atypical neuroleptic drug amisulpride, which acts as a selective blocker of dopamine D2 and D3 receptors. Furthermore, at low doses amisulpride has a selective preference for presynaptic dopamine autoreceptors, while at high doses it manifests a preferential action at post-synaptic dopamine receptors. We found amisulpride to be a potent antinociceptor agent in the mouse tail-flick assay, with an ED50 of 36.6 mg/kg. This effect was antagonized by naloxone (P