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The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adole

The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adole

  1. ThirdEyeFloond
    Drug and Alcohol Dependence (Article in Press)
    doi:10.1016/j.drugalcdep.2009.01.022

    Christie A. Hartman, Christian J. Hopfer, Brett Habersticka, Soo Hyun Rhee, Thomas J. Crowley, Robin P. Corley, John K. Hewitt and Marissa A. Ehringer

    Abstract
    Objective

    This study examined the genetic association between variation in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence symptoms.
    Method

    Adolescent and young adult subjects were recruited from three settings: a treatment program for youth with substance use disorders, the criminal justice system, and the community. A case–control sample consisted of 224 cases who endorsed at least one dependence symptom and 108 controls who tried cannabis but endorsed no symptoms. A family-based sample of 219 families was also analyzed.
    Results

    Case–control analysis identified a nominal association between SNP rs1049353 and having one or more cannabis dependence symptoms (p = .029), but the association did not hold up in a combined sample. Family-based analysis found a trend for the same SNP (p = .07). We did not replicate a previous report that SNP rs806380 was associated with the development of cannabis dependence.
    Conclusion

    These results provide inconclusive evidence of association between rs1049353/rs806380 and the development of cannabis dependence, and underscore the importance of replicating results of genetic association studies. Additional family-based studies are needed to clarify the role of the CNR1 gene, and its various SNPs, in the development of cannabis use disorders.