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The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic la

The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic la

  1. catseye
    Journal of Neurochemistry, 2007, 101, 87–98

    Jennifer L. Shoemaker, Kathryn A. Seely, Ronald L. Reed, John P. Crow and Paul L. Prather

    ABSTRACT:
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, paralysis and death within 2–5 years of diagnosis. Currently, no effective pharmacological agents exist for the treatment of this devastating disease. Neuroinflammation may accelerate the progression of ALS. Cannabinoids produce anti-inflammatory actions via cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), and delay the progression of neuroinflammatory diseases. Additionally, CB2 receptors, which normally exist primarily in the periphery, are dramatically up-regulated in inflamed neural tissues associated with CNS disorders.