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The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin k-Opioid System

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin k-Opioid System

  1. catseye
    Benjamin B. Land, Michael R. Bruchas, Julia C. Lemos, Mei Xu, Erica J. Melief, and Charles Chavkin

    The Journal of Neuroscience, January 9, 2008 • 28(2):407– 414 • 407

    Stress is a complex human experience having both positive and negative motivational properties. When chronic and uncontrollable, the adverse effects of stress on human health are considerable and yet poorly understood. Here, we report that the dysphoric properties of chronic stress are encoded by the endogenous opioid peptide dynorphin acting on specific stress-related neuronal circuits...