1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

The Effects of Agonists of Ionotropic GABAA and Metabotropic GABAB Receptors on Learning

The Effects of Agonists of Ionotropic GABAA and Metabotropic GABAB Receptors on Learning

  1. Basoodler
    The Spanish Journal of Psychology
    2009, Vol. 12, No. 1, 12-20

    The research described here investigates the role played by inhibitory processes in the discriminations made by
    the nervous system of humans and animals between familiar and unfamiliar and significant and nonsignificant
    events. This research compared the effects of two inhibitory mediators of gamma-aminobutyric acid (GABA):
    1) phenibut, a nonselective agonist of ionotropic GABAA and metabotropic GABAB receptors and 2) gaboxadol
    a selective agonist of ionotropic GABAA receptors on the process of developing active defensive and inhibitory
    conditioned reflexes in alert non-immobilized rabbits. It was found that phenibut, but not gaboxadol, accelerates
    the development of defensive reflexes at an early stage of conditioning. Both phenibut and gaboxadol facilitate
    the development of conditioned inhibition, but the effect of gaboxadol occurs at later stages of conditioning and
    is less stable than that of phenibut. The earlier and more stable effects of phenibut, as compared to gaboxadol,
    on storage in memory of the inhibitory significance of a stimulus may occur because GABAB receptors play the
    dominant role in the development of internal inhibition during an early stage of conditioning. On the other hand
    this may occur because the participation of both GABAA and GABAB receptors are essential to the process. We
    discuss the polyfunctionality of GABA receptors as a function of their structure and the positions of the relevant
    neurons in the brain as this factor can affect regulation of various types of psychological processes.
    Keywords: learning, defensive reflex, internal inhibition, discrimination, GABA, GABAA and GABAB receptors,
    phenibut, gaboxadol

    Evgeniya A. Zyablitseva, Nikolay S. Kositsyn, and Galina I. Shul’gina
    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences (Russia)