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The Effects of Baclofen on Calcium Channel Currentsin Dorsal Sensory Cells of the Spinal Cord in the

The Effects of Baclofen on Calcium Channel Currentsin Dorsal Sensory Cells of the Spinal Cord in the

  1. mersann
    The Effects of Baclofen on Calcium Channel Currents in Dorsal Sensory Cells of the Spinal Cord in the Lamprey

    Authors: I. V. Batueva, J. T. Buchanan , E. A. Tsvetkov, A. K. Sagatelyan and N. P. Veselkin

    Neuroscience and Behavioral Physiology, Vol. 29, No. 1, 1999

    Translated from Rossiiskii Fiziologicheskii Zhurnal imeni 1. M. Sechenova, Vol. 83, No. 11-12,
    pp. 92-104, November-December, 1997. Original article submitted May 6, 1997.

    First abstract sentences:

    Dorsal sensory cells isolated from the spinal cord of the lamprey species Ichthyomyzon uni-
    cuspis and Lampetra fluviatilis were used for whole-cell patch-clamp studies of the effects of
    baclofen on calcium channel currents, evoked in conditions in which Na +, K + currents were
    blocked, by depolarizing membranes from constant holding potentials of -100 or --80 mV
    to +30 mV. Ba ions were used as carriers of currents through calcium channels. These studies
    demonstrated that baclofen (0.5 mM) decreased the peak amplitude of the Ba2+ current by
    an average of 22.5 +/- 4.2% (n = 12) in dorsal sensory cells of the lamprey Ichthyomyzon
    unicuspis and by 28.4 +/- 3.3% in the dorsal sensory cells of Lampetra fluviatilis (n = 25).
    The conductivity of dorsal sensory cell membranes in the presence of baclofen (and GABA)
    did not change.
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