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The Effects of Cocaine Free Extracts of the Coca Leaf on Food Consumption and Locomotor Activity (19

The Effects of Cocaine Free Extracts of the Coca Leaf on Food Consumption and Locomotor Activity (19

  1. Bajeda
    Pharmacology Biochemistry and Behaviour 1981 May;14(5):725-8

    Bedford JA (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Wilson MC (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Elsohly HN (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Elliott C (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Cottam G (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Turner CE (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).

    The effects of two cocaine free fractions of an ethanol extract of the coca leaf (E. coca) were compared using actometric and limited access food consumption paradigms in rats. Several intraperitoneal doses of two different fractions were tested in both procedures. Neither of the fractions produced any alteration in locomotor activity, Both fractions did, however, produce reductions in food consumption at two or more of the doses tested. The results clearly demonstrate that the coca leaf contains constituents other than cocaine that are biologically active.
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