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The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers

The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers

  1. Gradient
    C. Benvenuti1, 2, 3, V. Bottà2, M. Broggini2, V. Gambaro3, F. Lodi3 and M. Valenti1

    Summary We have studied the single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets in a cross-over study in 6 healthy volunteers (median age 28 years). The formulations had similar systemic availability.
    Compared with oral tablets the sublingual route gave a lower peak concentration and a delayed peak time, while drops gave a greater maximum concentration with a similar peak time.
    The use of drops is suggested for a more marked initial effect and the sublingual route for easier administration, especially in the elderly.
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