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The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescripti

The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescripti

  1. Bajeda
    Walsh SL, Nuzzo PA, Lofwall MR, Holtman JR Jr. (2008). The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. Drug Alcohol Depend. Jul 7.

    Abuse of prescription opioids has risen precipitously in the United States. Few controlled comparisons of the abuse liability of the most commonly abused opioids have been conducted. This outpatient study employed a double-blind, randomized, within-subject, placebo-controlled design to examine the relative abuse potential and potency of oral oxycodone (10, 20 and 40mg), hydrocodone (15, 30 and 45mg), hydromorphone (10, 17.5 and 25mg) and placebo. Healthy adult volunteers (n=9) with sporadic prescription opioid abuse participated in 11 experimental sessions (6.5h in duration) conducted in a hospital setting. All three opioids produced a typical mu opioid agonist profile of subjective (increased ratings ofoxycodone was roughly equipotent to or slightly more potent than hydrocodone. Hydromorphone was only modestly more potent (less than two-fold) than either hydrocodone or oxycodone, which is inconsistent with prior estimates arising from analgesic studies.

    These data suggest that the abuse liability profile and relative potency of these three commonly used opioids do not differ substantially from one another and suggest that analgesic potencies may not accurately reflect relative differences in abuseliability of prescription opioids. liking, good effects, high and opiate symptoms), observer-rated, and physiological effects (miosis, modest respiratory depression, exophoria and decrements in visual threshold discrimination) that were generally dose-related. Valid relative potency assays revealed that

Recent Reviews

  1. poirot
    Version: 2008-10-16
    My pain management doctor will not prescribe long-acting prescriptions for people with chronic pain. He gave me a steroid injection using the anesthesia fentanyl (which does not affect me) and it had no effect at all; the site of the injection is an unfused cervical spine from an accident/surgery in January 2002. What was so hilarious is that he:
    1. Was weaning me slowly of of hydrocodone/apap 10/325 from 150 quantity a month to eventually 60,
    2. He had financial interest at the day hospital in which the injection happened,
    3. He was unable to recognize me and know what method of pain management I was on,
    4. He wrote me a script for oxycodone/acetaminophen 10/325 to take every 6 hours for 10 days!
    The injection, of course, had no effect since he was (injecting) into an empty space. I would rather use kratom than narcotics because I worry about my body. I have no death wish. I am not an addict. I suffer from constant pain that can be controlled by narcotics I wish not to take. They scare me.
    This doctor is with a group of approximately 350 physicians, under scrutiny of the DEA. I had to make an appointment with a Nurse Practitioner which is going to occur this Friday, Sept. 6th. The office is small but crowded in a smaller town in which I live in but not that far away. I am angry about this. It makes no logical sense and I think logically. I think. What would you do if you where in my position?