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The spin trap reagent a-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of

The spin trap reagent a-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of

  1. Anonymous
    European Journal of Pharmacology 280 (1995) 343-346
    Colado et al

    Abstract
    Administration of a single dose (10 mg/kg i.p.) of 3,4-methylenedioxy-metamphetamine (MDMA or 'ecstasy') produced a 40% loss of 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cortex and hippocampus of Dark Agouti rats 7 days later. Binding of [³Hparoxetine to the presynaptic 5-HT nerve terminals in cortex was decreased by approximately 30%. Injection of the spin trap reagent a-phenyl-N-tert-butyl nitrone (PBN) 150 mg/kg i.p.) 10 min prior and 120 min post MDMA administration totally prevented the loss in [³H]paroxetine binding in the cortex and attenuated the loss of 5-HT and 5-HIAA in both brain regions. PBN alone had no effect on [³H]paroxetine binding or brain 5-HT content. These data suggest that MDMA produces neurodegeneration of 5-HT neurones because of reactive free radical formation.