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Time Dependant Changes in Cocaine-Seeking Behaviour and Extra-Cellular Dopamine Levels in the Amygda

Time Dependant Changes in Cocaine-Seeking Behaviour and Extra-Cellular Dopamine Levels in the Amygda

  1. Jatelka
    Neuropsychopharmacology 19:48–59, 1998

    Ly T.L. Tran-Nguyen, Ph.D., Rita A. Fuchs, M.A., Greg P. Coffey, B.S., David A. Baker, M.A., Laura E. O’Dell, Ph.D., and Janet L. Neisewander, Ph.D.

    Abstract
    Cocaine and cocaine-associated cues elicit craving in addicts and reinstate cocaine-seeking behavior in rats. Craving and cocaine-seeking behavior may be mediated by withdrawal-induced changes in dopamine (DA) neurotransmission in the amygdala. To examine whether there are concomittant changes in cocaine-seeking behavior and extracellular DA levels during withdrawal, experimental rats were trained to self-administer cocaine (0.75 mg/kg IV). After 14 daily 3-hour training sessions, animals underwent either a 1-day, 1-week, or 1-month withdrawal period. Extracellular DA levels were assessed during baseline, extinction, cue reinstatement, and cocaine (15 mg/kg IP) reinstatement of cocaine-seeking behavior (i.e., defined as the difference in nonreinforced lever presses on an active minus inactive lever). Cocaine-seeking behavior became more intense during the course of cocaine withdrawal. Additionally, basal and cocaine-induced extracellular DA levels were enhanced after the 1-month withdrawal period. We suggest that the former may reflect a persistent elevation in tonic extracellular DA levels in the amygdala, whereas the latter may reflect a persistent elevation in phasic extracellular DA levels.