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Tonic analgesic effects of Δ9-tetrahydrocannabinol as measured with the formalin test [1980]

Tonic analgesic effects of Δ9-tetrahydrocannabinol as measured with the formalin test [1980]

  1. Behrang
    European Journal of Pharmacology Volume 61, Issue 3, 8 February 1980, Pages 313–315

    Donald E. Moss, Richard L. Johnson

    Abstract:
    The analgesic effects of Δ9-tetrahydrocannabinol (THC), the psychoactive component of marihuana, were tested using the formalin test. Rats were treated with either THC (5 mg/kg or 10 mg/kg) or a placebo by gavage 4 h before the formalin test for analgesia was initiated. THC produced a highly significant analgesic effect against both phasic pain and tonic pain. THC is discussed as a model for the development of new analgesics or as a suitable analgesic if used with another potentiating drug.

    Keywords:
    Tetrahydrocannabinol, Analgesia, Pain

    http://www.sciencedirect.com/science/article/pii/001429998090134X