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Traditional aqueous kava extracts inhibit cytochrome P450 1A2 in humans: Protective effect against e

Traditional aqueous kava extracts inhibit cytochrome P450 1A2 in humans: Protective effect against e

  1. Bajeda
    Clinical Pharmacology and Therapeutics 2005 May;77(5):453-4

    Russmann S (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Lauterburg BH (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Barguil Y (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Choblet E (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Cabalion P (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Rentsch K (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Wenk M (http://www.ncbi.nlm.nih.gov/sites/e...l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).

    Our results suggest that traditional kava drinking inhibits CYP1A2. After stopping kava consumption, the subjects did not smoke more, which could have induced CYP1A2, and a comparison with established caffeine metabolic ratios, which correspond to the values observed after kava consumption is stopped, also supports the interpretation that we observed a “deinhibition” rather than an induction of CYP1A2 after kava consumption was stopped.