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Transdermal and Oral dl-Methylphenidate–Ethanol Interactions in C57BL/6J Mice

Transdermal and Oral dl-Methylphenidate–Ethanol Interactions in C57BL/6J Mice

  1. testodan
    We tested the hypothesis that C57BL/6J mice will model human metabolic interactions
    between dl-methylphenidate (MPH) and ethanol, placing an emphasis on the MPH
    transdermal system (MTS). Specifically, we asked: (1) will ethanol increase d-MPH biological
    concentrations, (2) will MTS facilitate the systemic bioavailability of l-MPH, and (3) will l-MPH
    enantioselectively interact with ethanol to yield l-ethylphenidate (l-EPH)? Mice were dosed
    with MTS (14
    of a 12.5 cm2 patch on shaved skin) or a comparable oral dl-MPH dose (7.5 mg/kg),
    with or without ethanol (3.0 g/kg), and then placed in metabolic cages for 3 h. MPH and EPH
    isomer concentrations in blood, brain, and urine were analyzed by gas chromatographic–mass
    spectrometry monitoring of N-(S)-prolylpiperidyl fragments. As in humans, MTS greatly facilitated
    the absorption of l-MPH in thismouse strain. Similarly, ethanol led to the enantioselective
    formation of l-EPH and to an elevation in d-MPH concentrations with both MTS and oral MPH.
    Although only guarded comparisons between MTS and oral MPH can be made due to routedependent
    drug absorption rate differences,MTS was associated with significant MPH–ethanol
    interactions. Ethanol-mediated increases in circulating concentrations of d-MPH carry toxicological
    and abuse liability implications should this animal model hold for ethanol-consuming
    attention-deficit hyperactivity disorder patients or coabusers

Recent Reviews

  1. Veksul
    Veksul
    5/5,
    Version: 2011-03-11
    Very factual information, including not only oral Methylphenidate + Ethanol interactions, but transdermally as well.