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Transfer of dexamphetamine into breast milk during treatment for attention deficit hyperactivity dis

Transfer of dexamphetamine into breast milk during treatment for attention deficit hyperactivity dis

  1. Jatelka
    British Journal of Pharmacology 2007 March; 63(3): 371–375

    Kenneth F Ilett, L Peter Hackett, Judith H Kristensen, and Rolland Kohan

    What is already known about this subject: There are presently no published data on dexamphetamine transfer into breast milk or on its effects in the breast-fed infant.
    What this study adds: We have provided quantitative data on the absolute and relative infant doses of dexamphetamine for the breast-fed infant. We have also documented a lack of overt adverse effects in breast-fed infants despite measurable dexamphetamine concentrations in the infants’ plasma. Hence we now make recommendations for infant safety and monitoring when mothers taking the drug wish to breastfeed.

    Aims: To investigate dexamphetamine transfer into milk, infant doses and effects in the breast-fed infant.
    Methods: Four women taking dexamphetamine, and their infants were studied.
    Results: The median maternal dexamphetamine dose was 18 mg day−1 (range 15–45 mg day−1). Median (interquartile range) descriptors were 3.3 (2.2–4.8) for milk/plasma ratio, 21 µg kg−1 day−1 (11–39) for absolute infant dose and 5.7% (4–10.6%) for relative infant dose. No adverse effects were seen. In three infants tested, dexamphetamine in plasma was undetected in one (limit of detection 1 µg l−1) and present at 18 µg l−1 and 2 µg l−1 in the other two.
    Conclusion: Dexamphetamine readily transfers into milk. The relative infant dose was