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Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point

Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point

  1. Spucky
    Differential access to cocaine self-administration produced two patterns of drug
    intake in rats. With 1 hour of access per session, drug intake remained low and
    stable. In contrast, with 6 hours of access, drug intake gradually escalated over days.
    After escalation, drug consumption was characterized by an increased early drug
    loading and an upward shift in the cocaine dose-response function, suggesting an
    increase in hedonic set point. After 1 month of abstinence, escalation of cocaine
    intake was reinstated to a higher level than before. These ├×ndings may provide an
    animal model for studying the development of excessive drug intake and the basis
    of addiction

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