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Treatment for Methaqualone Dependence in Adults (Cochrane Review, 2007)

Treatment for Methaqualone Dependence in Adults (Cochrane Review, 2007)

  1. Jatelka
    Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD004146. DOI: 10.1002/14651858.CD004146.pub2.

    McCarthy G, Myers B, Siegfried N.

    Abstract
    Background
    Methaqualone is a potent quinazoline, a class of sedative-hypnotics, that has a high potential for abuse. While the oral use of methaqualone (Quaalude, Mandrax) has waned in western countries since the mid-late 1980's, the practice of smoking methaqualone is a serious public health problem in South Africa, other parts of Africa and India. In the context of diminishing resources devoted to substance abuse treatment in regions affected by methaqualone abuse, it would be desirable to base treatment on the best evidence available. This review aimed to provide health care workers, policy-makers and consumers with the necessary information to make decisions regarding effective treatment of this highly dependence-producing drug.

    Objectives
    To compare the effectiveness of any type of pharmacological or behavioural treatment administered in either an in-patient or out-patient setting compared with either a placebo or no treatment or a waiting list, or with another form of treatment administered in either an in- or out-patient setting.

    Authors' conclusions
    To date, no randomized controlled trials appear to have been conducted. Consequently, the effectiveness of inpatient versus outpatient treatment, psychosocial treatment versus no treatment, and pharmacological treatments versus placebo for methaqualone abuse or dependence has yet to be established.