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Zolpidem Involvement on Memory and Hypnotic Effect of Ethanol in Chronically Ethanol Treated Rats (1

Zolpidem Involvement on Memory and Hypnotic Effect of Ethanol in Chronically Ethanol Treated Rats (1

  1. Jatelka
    Alcohol Alcohol. (javascript:AL_get(this, 'jour', 'Alcohol Alcohol.');) 1999 Jul-Aug;34(4):511-9.

    P. Mikolajczak, I. Okulicz-Kozaryn, K. Szczawinska, E. Kaminska, K. Kus

    Multiple (10x) treatment of zolpidem (1.0 or 2.0 mg/kg, orally, p.o.) led to different effects in chronically ethanol-treated and control rats. In control rats, after repeated zolpidem administration, a weaker, when compared to single administration, hypnotic effect of ethanol was observed, which may be the result of tolerance developed towards the inhibitory effect of zolpidem. However, in chronically ethanol-treated rats, the multiple zolpidem treatment led to prolongation of ethanol-induced sleep similar to the values observed in non-zolpidem-treated control animals. This suggests that zolpidem multiple administration may inhibit tolerance towards ethanol in chronically ethanol-treated rats. In the experiment with zolpidem, there were effects on performance in a memory test and the impairment of passive avoidance task after multiple drug treatment when compared to the effects after single administration in control rats. In contrast, in chronically ethanol-treated rats, amplification of latency (especially after 2.0 mg/kg) was observed. The possible relationship between ethanol-induced sedation and latency values would be consistent with a higher contribution of the inhibitory effect of zolpidem, than a direct influence on memory processes in chronically ethanol-treated rats.

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