2C-I has been a great chemical for SWIM. It hasn't been as powerful or enlightening as 2C-E, but it has helped this former introvert come out of his shell. However, a friend of SWIM's had some negative aftereffects from her lone 2C-I trip. She had a lot of fun during the trip, but felt confused and anxious for weeks afterwards - this unpleasantness didn't go away until a 2C-E trip helped her heal. I found out later that she was drunk when she took the 2C-I. I have had no trouble mixing moderate amounts of alcohol with 2C-I, but he always had the drinkies after he took the chemical, not before. We all know psychedelics can lead to permanent mental changes, not all of them good; has anyone else seen something like this from 2C-I?