I would like to start a thread that has lots of various information on hydrocodone all in one place. Please forgive me if any of the subject matter is redundant, I am merely trying to consolidate the information. Feel free to add to below topics. I ask everyone for their input on these matters: 1. How quickly did you's tolerance develop and with what frequency of use? 2. Did grapefruit juice and/or Tagmat really work for potentiating effects? 3. Theraputic vs. Rercreational doses and/or experiences. 4. Your feelings on you's use. 5. Additoinal comments 6. Any tips on quickening the reduction of tolerance? Swim first had hydros this time last year. SWIM aquired about 20 7.5/500. He started with one and then in about three days he upped it to 2 at once and then within a week it was one and a half followed by another every hour with a max of 4 per day. The supply was gone within two weeks, and sWIM was happy with the effects, the buzz remained about the same throughout the couple weeks. Then in the summer he aquired a few 5/500's and took one and a half for a decent buzz. In october he took one 7.5/500 and felt nothing so he followed it with another after 2 hours nad went to bed with no effects. Half way through the night he woke up buzzing and coudln't fall back to sleep. I think its because of the acidic meal he had at dinner before ingestion of the pills. A weel later he decided to try on 7.5 again and felt an OKAY buzz. The next day it took 2 7.5's to get a buzz, then the suply was gone. Now in november, about a month of no opiates he took two 100mg propoxy-n. This was a different more energetic buzz, not as enjoyabe to but definitely somehting. Then two weeks later he took two 7.5's and noticed a tolerance. December, doctor prescribed 40 50mg Tramadol and went through the bottle in 2 weeks. Not a nice buzz, way too energetic and not too enjoyable. Bad comedown. Then a week later he took 20mgs of hydro and felt real nice. Two days later 20mgs did nothing and he needed to take 20mgs more to feel a nice buzz. I am deeply saddened about his tolerance and his apparent habit. The next day, he regiments himself with 15mgs followed by 10mg every 45 min for a total of 35 mgs hydrocodone. Definite difference from the previous night's intesne high from about 45mgs. I know he definitely needs to quit for at least a month to lower his tolerance. I would liek to lower it to 5mgs for an theraputic dose and avoid recreatinal use all together. He suspects he would use about 5-7.5 mgs twice a day twice a week, so about 4-5 pills a week. In february do you think 5mgs would be an effective dose? I am very unhappy about having let himself get addicted to the pills and abusing them recreationally rather than to treat his chronic pain due to arthritis in the spine. Overall since last year, SWIM only had about 20 experiences with hydrocodone and the intensity and length have significantly descreased as well as a unexpected rapid increase in tolerance. SWIM just wants to stop recreational use and use the pills for theraputic use only. How long does it take tolerance to develop in patients who use 5/500 twice a day on an every-other-day basis? And at what rate does the tolerance increase? For example would he up the does 2.5mgs every month or longer? ABOUT POTENTIATION... I tried twice to potentiate his experiences with grapefruit juice an hour before the first time and an hour after the second. In both scenarios I took antacids and didn't notice any effect. In fact he believes that the experience was lessened by the grapefruit juice. Maybe he'll try again sometime. Please contribute any relevant information on the subjects covered. Also, maybe the moderators can consider making a seprate Section for hydrocodone like there is for codeine, opium and others.