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Drug info - α-PVP Drug Info

Discussion in 'Beta-Ketones' started by Terrapinzflyer, Jan 16, 2012.

  1. Terrapinzflyer

    Terrapinzflyer MDMA, RC & News Forums Platinum Member & Advisor

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    Can anyone add information about alpha-Pyrrolidinopentiophenone a-pvp


    • names / synonyms
    • molecule
    • dose
    • duration
    • side effects
    • legal status
    • have there been any reported incidents with this compound?
    • since when has this research chemical been available?
    • stability of the molecule / compound

    [​IMG]

    Names: Alpha-pvp, a-pvp, alpha-Pyrrolidinopentiophenone , 0-2387


    IUPAC Name: 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone
    CAS Number: 14530-33-7 , 5485-65-4 (HCl)
    Formula: C15H21NO
    Mol. Mass 231.333 g/mol

    This substance was patented in 1967 by a German company. It is a stimulant drug related to pyrovalerone. Pharmacology is unknown, but theorized to be a NDRI (norepinephrine-dopamine reuptake inhibitor)

    Current legal status unclear. In the US it would be criminalized federally by the pending HR 1254. Could potentially be prosecuted under analog laws.




    Experiences with a-pvp should be discussed here: a-pvp Experience Reports


    These documents are in the Archives:
    a-pvp patent


    Research Chemicals Index - Phenethylamines
    Research Chemicals Index - Tryptamines
    The Research Chemical Index
    Research Chemicals Index - Beta-Ketones
    Research Chemicals Index - Synthetic Cannabinoids
    Research Chemicals Index - Piperazines
     

    Attached Files:

    Last edited: Jan 16, 2012
  2. Tech House

    Tech House Titanium Member

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    Re: a-pvp Drug Info

    It must be a releaser of NE and D as well as an NDRI based on another site's experience reports, which tell of fairly immediate effects upon insufflation, combined with fairly short experiential (as opposed to serum concentration) half-life. Moab, or "Man on a bus" who I see occasionally, ordered some of it and I'll report back about his experience after I see him.

    As for legal status, I looked that up because I worry about Moab's online buying behavior, and it seems that a-pvp is already technically illegal in many states such as Texas. However, I find it very difficult to decipher legal status of new RCs because the laws are too complex for my concussion-addled brain to comprehend unless there is an explicit statement that Chemical X is illegal. If I don't see Moab again, I'll have to conclude that things didn't go well with his delivery.
     
  3. snapper

    snapper Gold Member

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    Re: a-pvp Drug Info

    alpha-pvp is almost as much of a disappointment as alpha-ppp and mdppp for the lab manager but if the ferrets had to pick their favorite, it would be this one. The effects are, like the other two, short acting and relatively mild. Of the three it is the only one that is not unpeasant to smoke but it does not really have other effects past a gentle stimulation and motivation enhancement. Euphoria is minimal but is there and when the ferrets first tried it at the tail of an epic (and their last) MDPV binge, it was barely effective. Like all the MDPV analogs, it is a disappointment in that the high is not nearly so intense, but then again neither are the side effects. It did not trigger any psychosis, vasoconstriction was minimal, the stimulation was smooth and lucid, and did not cause confusion or mental burnout that MDPV inevitably dose at higher doses. The ferrets tried IV once but had a massive tolerance and all they could say was that it was underwhelming (probably akin to their feelings about the other two.
    The lab manager may acquire a sample of mppp soon and will try that last, but does not expect anything interesting. Note that this trial was actually some time ago; the ferrets are still on their stimulant hiatus and any further experiments will be in the future.
    The lab manager is really disappointed with all of these and does not plan to use them again. The one benefit they have is a very short duration of action and minimal side effects and comedown. This of course translates, as expected, to the lack of any high. Meth, cocaine, and PV fans, unless the batch assayed is of poor quality, you are all bound to be disappointed. However, every ferret's biology is different and some may enjoy these...
     
  4. ToastedWasp

    ToastedWasp Newbie

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    Re: a-pvp Drug Info

    There is a huge difference in batches for this chem. The results from the first batch were really satisfying, the next batch was total garbage. Huge disappointment in the difference.
     
  5. Synesthesiac

    Synesthesiac R.I.P. Palladium Member

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    Re: a-pvp Drug Info

    Can anyone comment on the legality of this compound in the UK?

    I presume its covered by the same law that covers MDPV, but i'm no expert on UK laws.
     
  6. Synthesised

    Synthesised Titanium Member

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    Re: a-pvp Drug Info

    Yes, this would be covered by the cathinone laws as of April 2010
     
  7. m3c420

    m3c420 Newbie

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    Re: a-pvp Drug Info

    Can someone post some pictures of a-pvp being vaporized - for comparison
     
  8. Synthesised

    Synthesised Titanium Member

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    Re: a-pvp Drug Info

    Comparison to what?

    I found 20mg snorted to be an ample dose. Going higher resulted in elevated heart rate, (mild) anxiety and insomnia. the comedown was unpleasant.

    Redosing and dosing too high made for an unpleasant comedown too. Like that given to me by ethylphenidate and methylphenidate (ritalin).

    There is a good drive to socialise, an increased sex drive and good mood lift, although these only last around 1-1.5 hours. I enjoyed this and would do it again over pentedrone and MDPPP which I have also tried.
     
  9. smark

    smark Silver Member

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    Re: a-pvp Drug Info

    I agree the first batch i had was rocketfuel, the secoond utterly useless, im at the point of finishing a g just to see what happens as im around 300mg in and not amused with the lack oif quality

    smark added 1 Minutes and 21 Seconds later...

    I dont have photos but on tinfoil it turns a yellow oily colour and leaves no trace(the batch i had anyway)
     
    Last edited: Jul 4, 2012
  10. syntheticdave

    syntheticdave Newbie

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    Re: a-pvp Drug Info

    Sounds like you had a pretty bunk batch i defiantly agree with Synthesised that 20mgs is a sufficient dose.
     
  11. smark

    smark Silver Member

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    Re: a-pvp Drug Info

    I actually resorted to vaping some on tinfoil and it was much more active but still had to do a fair bit, got to sleep no problem as well.

    As i stored the foil and straw in the same box as the apvp i did notice after snorting a line of apvp there was an odour of the vaped residue so maybe storage in cheap baggies by vendors may be an issue
     
  12. psychedelaholic

    psychedelaholic Silver Member

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    Re: α-pvp

    I found a-PVP to be quite nice. Snorted few lines but much preferred vaping it. Strongish rush and nice buzz. Much shorter lasting than MDPV but doesn't make you go instantly insane like PV does. No voices in your head, no conspiracy theories, no one out to get you lol. Once it wears off I found I became uber tired, like being able to fall alseep at my work desk whilst my eyes were still open.
     
  13. Synesthesiac

    Synesthesiac R.I.P. Palladium Member

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    Re: α-pvp

    I would describe this as a mild version of MDPV, without as much paranoia or psychosis. Warning to all users: If you re dose with this chemical for more than a few hours you will get cravings when it wears off. If you re dose for more than 12 hours you will get paranoia cravings and anxiety when it wears off. More than 24 hours and when it wears off expect psychosis level paranoia.

    This is judging from posts on another forum, and some users recurrent habit of doing too much of this chemical whilst not having benzodiazepines to hand to help the after stimulation. Starts off good and positive with productive posts, but usually ends with a day or two of "The shadow people are still after me" type posts.

    Dosage Intranasally: Varies from 5mg threshold, 10mg weak, 15-20mg average, 25-35mg strong.
    Duration: 30-90 minutes. After stimulation can last an hour or two.
     
  14. Neurosees

    Neurosees Silver Member

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    Re: α-pvp

    I know someone who smoked about 30mg of α-pvp and went from baseline straight to psychosis-level paranoia within 20 minutes. It was not a panic attack, it was real paranoid psychosis that lasted for about 12 hours with transient delusions persisting about 48 hours. This individual is more inclined to paranoid thoughts to begin with but this is a very potent stimulant nonetheless.
     
  15. stryder09

    stryder09 Silver Member

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    Re: α-pvp

    Does anyone know of any literature that details alpha-PVP's mechanism of action in the human body? Or even rat models?

    I don't think the information exists. But I could be overlooking it.
     
  16. Alfa

    Alfa Productive Insomniac Staff Member

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    Re: α-pvp

    Could you please share more information about this?
     
  17. asloan471

    asloan471 Newbie

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    Apvp hcl?

    I recently recieved what is said to be APVP HCL Cas #5485-65-4. What I have is a white crystals but when vaped on tin foil burns and turns into a nasty smoke, Nothing like thje APVP ive had in the past, would this be correct for the hcl? If so what method would i use to convert to FB?
     
  18. Subflow22

    Subflow22 Newbie

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    Get glass eye dropper tubes from Walgreens. Break / chip / melt the tip so that the narrow dropper portion of the glass tube is removed. Get some poly tubing (heat resistant) which is available at Home Depot, or the type of tube you buy to replace the one on marijuana vaporizer. Cut the tip off of the rubber squeeze bulb, create just enough of a hole to firmly fit your tubing.

    You now have a very efficient and cost effective portable vaporizing tube that allows you to easily see the material you are trying to vape. This is priceless with a-PVP, as it easily burns if heated too much or too quickly. A 1$ tube should last you though an entire gram with practice. If you burn the material and the tube becomes opaque, so what? Throw that 1$ tube away and replace it.

    This method works equally well for the tan, powdery material as well as the chunky / rocky material. Just make sure you apply enough heat to melt the material in the tube before you pull.

    VERY little material is lost this way. Seriously, FUCK FOIL. Make your PV last!
     
  19. Subflow22

    Subflow22 Newbie

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    Re: α-pvp

    I assume you are quite certain that this person vaped pvp and not mdpv? I trust you are.

    I, personally, have gone on binges as long as 5 straight days, vaping (cleanly) as much as a gram a day. I have gone through extended binges of the white powdery, the redish rocky and tan powdery varieties. I have indeed noticed some increased paranoia, particularly with the white varieties, though never anything unmanageable.

    The only time I have EVER experienced psychosis on a-PVP was when I took a double dose of Ambien CR and, rather than sleep, I blacked out. Just wanted to add 2c here, as it appears that prevalence of psychosis is largely contingent upon the individual.
     
  20. drwoood

    drwoood Newbie

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    Like MDPV, alpha-PVP inhibits the reuptake of dopamine and noradrenaline, and is significantly stronger at inhibiting the reuptake of dopamine. Its IC50 for dopamine reuptake is 52 nM; it's IC50 for noradrenaline uptake is 200 nM - lower numbers mean that it is stronger. See Meltzer et al (2006) '1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogues: a promising class of monoamine uptake inhibitors' J Med Chem, 49, 1420-1432.

    Both a-PPP and MDPV are significantly more selective for the dopamine transporter vs the noradrenaline transporter than dexamphetamine or methylphenidate.

    drwoood added 95 Minutes and 47 Seconds later...

    I made a mistake in the post above - the IC50 for NE uptake is 56, rather than 200 (I read the wrong column in the paper I cited) - making alpha-PPP less selective for the dopamine transporter than I thought.
     
    Last edited: Nov 13, 2012