Pharmacology - activity of these chems? 5-meo-det and unexplored tryptamines

Discussion in 'Tryptamines' started by allyourbase, Apr 5, 2005.

  1. allyourbase

    allyourbase Palladium Member

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    5-Bromo-N,N,-dimethyltryptamine


    5-chloro-N,N,-dimethyltryptamine


    5carboxamidotryptamine maleate


    5-Fluoro-N,N,-Dimethyltryptamine


    5-Hydroxy-N-OMEGA-methyltryptamine oxylate


    5-iso-propyl-N,N-dimethyltryptamine


    5methoxybarbonylamino-N-acetyltryptamine


    5-MeO-DET (is it is bad as shulgin says?)


    a-Methyl-5-hydroxytryptamine maleate


    dansyl tryptamine


    Omega-Methyltryptamine


    alpha methyltryptamine methylsulfanate??


    are any of the fluoros active?
     
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  2. Labrat

    Labrat Newbie

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    A wild guess is that a active 5-hydroxy tryptamine will have a nasty effect. Bufotenineisa example of a nasty one.A fluorine will most likely behave like a hydrogen if attached on a aromatic ring system. So if ahydrogen version is active, the fluorine counterpart should be active too. DMT is active so 5-fluoro-DMT should absolutely be active. The N-methyltryptamines are not likely to be active.
     
  3. allyourbase

    allyourbase Palladium Member

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    badass, thanks for your input, one of the ones I have immense interest in would be the Omega Methyl tryptamine.....I wonder if its omega structure would have a similar effect to the alpha structure of AMT, allowing it to bypass MAO.... the 5-F-DMT seems interesting indeed.
     
  4. GDxCAT

    GDxCAT Titanium Member

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    Dont know about the rest but 5meo det is active (as im sure you know.)


    I have heard reports of pleasant effects being experienced at 0.5mg.


    This is only 3rd hand information, so take witha grain of salt.[​IMG]
     
  5. allyourbase

    allyourbase Palladium Member

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    yeah thats whatShulgin's source calleda"torture psychedelic". hmmm love to hear from somoene whos actually taken the stuff, it does appear to be rare, though one common source has it and Ive found two other chemical companies that claim to have it in stock. I just dont know exactly what it DOES. Shulgin didnt elaborate too much on that... in Tikhal he,or rather, the subjects,explained it as an odd intoxication and tinitus: from tikhal -


    QUALITATIVE COMMENTS : (with 2 mg, orally) "My tinnitus is really out there, and there is no way of getting away from it. Light-headed in a funny way -- no hypotension, not dizzy -- maybe something to do with the inner-ear? It is in the head, I am attentive, and I am not comfortable. Three hours into it I am down, and I have a bit of wine, and I am aware of it. Am I drunk? Was I drunk earlier? I was intoxicated, to be sure.


    (with 3 mg, orally) "It hit in a half hour, and the thought that came to mind was the phrase from my days at college, "Boy, I really felt that drink!" I may be sloppy, but let me explore the sexual. Wow. I may be spacey in the head, but my body knows where it is at. The next day was normal. I don't think I want to do this again."


    (with 3 mg, orally) "Effect felt within 20 mins., mainly light-headedness, almost dizziness. This blocked anything else. Just wanted to stay quiet and hope it would all go away as soon as possible. During the next hour, lying beside husband (who was experiencing the same effect but not minding it as much), I became aware of another dimension behind the dizziness. I could sense enough of it to believe that it would have been interesting to explore, but that there was no way to get through the dizzies, which effectively blocked anything else. At approximately the hour and a half to two-hour point, I felt a faint lessening of the head-fuzzies, and tested it out by walking to the living room. Felt it necessary to walk carefully. Body felt heavy and mood was rather dark, verging on depressed. After that, attempted love-making, which was extraordinarily successful for husband. For myself, there was still a reluctance to let down my guard. My back problems had been bothering me quite a bit, during all of this, and even two Bufferins didn't help as much as I would have liked. It's quite obvious that, if it were possible to remove the part of the molecule that causes the dizzies, this would be one of the best drugs for erotic stuff imaginable. And if wishes were horses, etc. Too bad. Would I try this again? And at a higher dosage? No, and No. "


    (10 mgs, smoked with peppermint leaves) "After a few minutes a high feeling with some dizziness, intense heartbeat, trembling, anxiety, restlessness, cold sweating, paleness and weak belly cramps. There were some visions I could not concentrate because of the strong side-effects. I felt sick, went to bed and was very glad when the effects disappeared after about one and a half hour."Edited by: allyourbase
     
  6. allyourbase

    allyourbase Palladium Member

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    wouldnt a-Methyl-5-hydroxytryptamine be alpha methyl seratonin?would the alpha methylation allow it into the brain the same way alpha methylation of tryptamine does??? I wonder.
     
  7. Labrat

    Labrat Newbie

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    Alpha-methylation does not specifically allow for entry of the CNS but rather makes it more sturdy towards the MAO-system. Alpha-methyl serotonin is probably too polar to pass the blood-brain barrier.
     
  8. fastandbulbous

    fastandbulbous Titanium Member

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    It going to light up all the 5HT3 receptors in the gut and produce a pukefest (it's in the Tocris catalogue and is listed as a 5HT agonist with mostly peripheral activity). Without the O-methyl group, taking it is going to be like being poisoned
     
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