Drug info - AL-LAD and ETH-LAD same thing?

Discussion in 'LSD' started by dala, Jul 25, 2012.

  1. dala

    dala Silver Member

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    Can someone clear this up for me, are these 2 the same or different analogues..
    And if they're different is one legal in the UK, AL-LAD and the other not. or are they seriously grey chems

    I know theres not much about them but just wondering,,
     
  2. Phenoxide

    Phenoxide Super Moderator

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    Nope, slightly different compounds. AL-LAD is the 6-allyl analogue of LSD, while ETH-LAD is the 6-ethyl analogue. The structural relationship between the LAD compounds documented in TiHKAL is shown in the schematic below (note the differing 6' modifications highlighted in blue).

    In terms of psychoactivity the compounds are all very similar. Shulgin notes some subtle differences between the experiences but that may just be usual trip-to-trip variability that one would expect even when taking the same psychedelic multiple times. The length of the 6' chain has a modest effect on potency, with the longer chained LAD compounds PRO-LAD and AL-LAD being slightly less potent than LSD. Even so they're still extremely potent - reportedly active in the 100 to 200 microgram range.

    LADcompounds.png

    N-alkyl derivatives of lysergamide are all class A controlled substances under the UK Misuse of Drugs Act 1971. ETH-LAD and PRO-LAD would certainly fall under this clause. AL-LAD may however not fall under it as strictly speaking allyl groups are not alkylations. This would be similar to the way in which 5-MeO-DMT is a controlled substance but 5-MeO-DALT is not. However there is certainly a potential grey area in the wording of the law there - it's certainly not as definitively defined as the clauses regarding phenethylamines or tryptamines.

    This might of course raise the question as to why it hasn't attained any sizeable interest to date. This may have something to do with the fact that the documented synthesis routes to this compound go via a number of watched or internationally controlled substances including LSD itself. Additionally the synthesis itself is also somewhat more sophisticated than that required for the more popular Shulgin compounds. It's certainly less complicated for a clandestine lab to pump out a kilo or two of 2C-E than it is to make LSD compounds.