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Combinations - Alprazolam & Antibiotics

Discussion in 'Benzodiazepines' started by Junket, Mar 18, 2009.

  1. Junket

    Junket Newbie

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    sooo swim did a search but didnt find anything on it directly......

    is it alright to mix the two?

    swim gets his wisdom teeth out tomorrow and was hoping to be really high afterwards just laying in bed....

    he has never done it. was gonna take .5mg or 1mg and just go with it
     
  2. Jatelka

    Jatelka Psychedelic Shepherdess Platinum Member & Advisor

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    Depending on the antibiotics, there may well be an interaction, if they are inhibitors of CYP3A, such as the macrolides clarithromycin and erythromycin (although these would be extremely odd choices post tooth extraction).

    Cytochrome inhibitors such as erythromycin could increase avalability of Alprazolam theoretically, but an abstract I found suggests that even though it inhibits CYP3A, erythromycin does NOT result in increased psychomotor side effects of Alprazolam (and, I guess, by inference, may not increase cognitive effects)

    A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism
    Clinical Pharmacology and Experimental Therapeutics 1996 May;59(5):514-9
    Yasui et al
     
  3. Junket

    Junket Newbie

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    [​IMG]
     
  4. Jatelka

    Jatelka Psychedelic Shepherdess Platinum Member & Advisor

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    ^^^ ????
     
  5. Junket

    Junket Newbie

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    hahaha... just the way you said that was like......... damn.......really?


    from what i gathered, there are no risks........