TEK - ancient coca preparations / extracts from the British pharmaceutical codex

Discussion in 'Coca' started by Benga, Sep 26, 2006.

  1. Benga

    Benga Platinum Member & Advisor

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    Vinum Erythroxyli (N. F.)—Wine of Erythroxylon.

    Related entry: Coca (U. S. P.)—Coca - Wines
    Other tomes

    SYNONYM: Wine of coca.

    Preparation.—"Fluid extract of erythroxylon (U. S. P.), sixty-five cubic centimeters (65 Cc.) [2 fl, 95]; alcohol, sixty-five cubic centimeters (65 Cc.) [2 fl, 95]; sugar, sixty-five grammes (65 Gm.) [2 ozs. av., 128 grs.]; claret wine, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl, 391]. Dissolve the sugar in about six hundred cubic centimeters (600 Cc.) [20 fl, 138] of claret wine, add the alcohol and fluid extract, and enough claret wine to make one thousand cubic centimeters (1000 Cc.) [33 fl, 391]. Let the mixture stand a few days in a cold place, if convenient, then filter, and pass enough claret wine through the filter to restore the original volume. Each fluid ounce represents 30 grains of erythroxylon (coca). Note.—In place of claret wine, any other palatable wine may be used, according to the demand or preference of the prescriber or consumer"—(Nat. Form.).

    Action, Medical Uses, and Dosage.—(See Coca.) Dose, 1 to 2 fluid drachms.

    Related Preparation.—VINUM ERYTHROXYLI AROMATICUM (N. F.), Aromatic wine of erythroxylon, Aromatic wine of coca. "Fluid extract of erythroxylon (U.S. P.) sixty-five cubic centimeters (65 Cc.) [2 fl, 95]; compound elixir of taraxacum (F. 111), ten cubic centimeters (10 Cc.) [162]; syrup of coffee (F. 367) twenty-five cubic centimeters (25 Cc.) [406]; port wine, one hundred and sixty-five cubic centimeters (165 Cc.) [5 fl, 278]; aromatic elixir (U. S. P.), three hundred cubic centimeters (300 Cc.) [10 fl, 69]; sherry wine, a sufficient quantity to make one thousand cubic centimeters (1000 Cc.) [33 fl, 391]. Mix the five first-named ingredients with four hundred cubic centimeters (400 Cc.) [13 fl, 252] of sherry wine. Let the mixture stand several days in a cold place, if convenient, then filter, and pass enough sherry wine through the filter to make the product measure one thousand cubic centimeters (1000 Cc.) [33 fl, 391]. Each fluid ounce represents 30 grains of erythroxylon (coca)"—(Nat. Form). Dose, 1 to 2 fluid drachms.



    ELIXIR COCAE, B.P.C.
    ELIXIR OF COCA.

    Related entry: Coca - Elixirs
    Other tomesMiscible Liquid Extract of Coca 16.50 | 3 fl.oz. 144 min.
    Simple Elixir ... to 100.00 | to 20 fl. ounces


    Mix.
    Dose.—4 to 15 mils (1 to 4 fluid drachms).

    EXTRACTUM COCAE, B.P.C.
    EXTRACT OF COCA.

    Related entries: Coca - Extracts
    Other tomesLiquid Extract of Coca 100.00 | 20 ounces


    Evaporate the liquid extract on a water-bath to the consistence of a firm extract.
    Dose.—1 to 6 decigrams (2 to 10 grains).


    EXTRACTUM COCAE LIQUIDUM MISCIBILE, B.P.C.
    MISCIBLE LIQUID EXTRACT OF COCA.Liquid Extract of Coca 100.00 | 20 ounces
    Alcohol (60 per cent.) ... to 100.00 | to 20 fl. ounces


    Concentrate the liquid extract to 50 (10 fluid ounces) by evaporation, pour off as much clear liquid from the residue as possible, wash the residue with 10 (2 fluid ounces) of water, mix the washings with the clear liquid, and add sufficient of the alcohol to make up to the required volume.
    Dose.—2 to 4 mils (1/2, to 1 fluid drachm).

    Extractum Cocae Liquidum, B.P.—LIQUID EXTRACT OF COCA.
    Coca leaves, in No. 20 powder, 100; alcohol (60 per cent.), sufficient to produce 100. Macerate the drug with 200 of alcohol for forty-eight hours, then transfer the mixture to a percolator, and percolate with sufficient alcohol to exhaust the drug. Reserve the first 75 of percolate; evaporate the remainder, at a temperature below 80°, to a soft extract, dissolve this in the reserved portion, and add sufficient alcohol to make up to the required volume. Liquid extract of coca is prescribed in mixture form or diluted with glycerin and syrup. It forms a turbid mixture with water, its waxy constituents being precipitated. Miscible liquid extract of coca is without this disadvantage. The content of total alkaloid in liquid extract of coca is very variable, ranging from 0.2 to 0.8 per cent., the average being about 0.38 per cent. This uncertainty in its composition causes the preparation to be little used. Dose.—2 to 4 mils (1/2 to 1 fluid drachm).

    EXTRACTUM COCAE, B.P.C.
    EXTRACT OF COCA.

    Related entries: Coca - Extracts
    Other tomesLiquid Extract of Coca 100.00 | 20 ounces


    Evaporate the liquid extract on a water-bath to the consistence of a firm extract.
    Dose.—1 to 6 decigrams (2 to 10 grains).


    EXTRACTUM COCAE LIQUIDUM MISCIBILE, B.P.C.
    MISCIBLE LIQUID EXTRACT OF COCA.Liquid Extract of Coca 100.00 | 20 ounces
    Alcohol (60 per cent.) ... to 100.00 | to 20 fl. ounces


    Concentrate the liquid extract to 50 (10 fluid ounces) by evaporation, pour off as much clear liquid from the residue as possible, wash the residue with 10 (2 fluid ounces) of water, mix the washings with the clear liquid, and add sufficient of the alcohol to make up to the required volume.
    Dose.—2 to 4 mils (1/2, to 1 fluid drachm).

    Extractum Cocae Fluidum (U. S. P.)—Fluid Extract of Coca.

    Related entry: Coca (U. S. P.)—Coca - Extracts and Fluid Extracts
    Other tomes

    SYNONYMS: Extractum erythroxyli fluidum (U. S. P., 1880), Fluid extract of erythroxylon.

    Preparation.—"Coca, in No. 40 powder, one thousand grammes (1000 Gm.) [2 lbs. av., 3 ozs., 120 grs.]; diluted alcohol, a sufficient quantity, to make one thousand cubic centimeters (1000 Cc.) [33 fl, 391]. Moisten the powder with four hundred and fifty cubic centimeters (450 Cc.) [15 fl, 104] of diluted alcohol, and pack it firmly in a cylindrical percolator; then add enough diluted alcohol to saturate the powder and leave a stratum above it. When the liquid begins to drop from the percolator, close the lower orifice, and, having closely covered the percolator, macerate for 48 hours. Then allow the percolation to proceed, gradually adding diluted alcohol, until the coca is exhausted. Reserve the first eight hundred cubic centimeters (800 Cc.) [27 fl, 25] of the percolate, and evaporate the remainder to a soft extract; dissolve this in the reserved portion, and add enough diluted alcohol to make the fluid extract measure one thousand cubic centimeters (1000 Cc.) [33 fl, 391]"—(U. S. P.).

    Description, Medical Uses, and Dosage.—(See Coca). Fluid extract of coca is of a deep greenish-brown or olive-brown color. It has the bitterness and astringency oft tie leaves, as well as the feebly aromatic, tea-like flavor. Its odor is slight. Dose, 10 to 60 minims.

    Tinctura Cocae, B.P.C.—TINCTURE OF COCA. 1 in 5.
    Used as a cerebral stimulant and gastric sedative. Dose.—2 to 4 mils (1/2 to 1 fluid drachm).
    Vinum Cocae, B.P.C.—COCA WINE. 1 (elixir) in 8.
    This is a strongly medicated wine. In order that it may be included in the class of medicated wines for sale without a wine licence, it must contain not less than half a grain of alkaloid per fluid ounce. Acts mainly in virtue of its cocaine. Coca wine differs from tea, in that the former beverage acts mainly on the motor areas and the latter on the psychical, Dose.—8 to 15 mils (2 to 4 fluid drachms) with water.


    Vinum Cocae et Quininae Phosphatis, B.P.C.—COCA AND QUININE PHOSPHATE WINE.
    Each fluid ounce contains 1 grain of quinine sulphate, 30 minims of liquid extract of coca, 4 minims of diluted phosphoric acid, with alcohol, detannated sherry and distilled water. Dose.—15 to 60 mils (1/2 to 2 fluid ounces)

    OCULENTUM ATROPINAE CUM COCAINA, B.P.C.
    ATROPINE EYE OINTMENT WITH COCAINE.

    Related entry: Coca
    Other tomesAtropine, in fine powder 1.00 | 5 grains
    Cocaine, in fine powder 2.00 | 10 grains
    Soft Paraffin, white 97.00 | 485 grains


    Dissolve.

    BUGINARIA COCAINAE, B.P.C.
    COCAINE NASAL BOUGIES.

    Related entry: Coca. In 1 Bougie
    Cocaine Hydrochloride 0.011 gramme | 1/6 grain


    Gelatin Basis, sufficient to fill a 1-gramme (15-grain) mould.

    GUTTAE COCAINAE, B.P.C.
    COCAINE EYE DROPS.

    Related entry: Coca - Eye drops
    Other tomesCocaine Hydrochloride 2.00 | 35 grains
    Sterilised Water ... to 100.00 | to 4 fl. ounces


    Dissolve the cocaine hydrochloride in the sterilised water.


    GUTTAE ZINCI CHLORIDI ET COCAINAE, B.P.C.
    ZINC CHLORIDE AND COCAINE EYE DROPS.Zinc Chloride 0.50 | 2 grains
    Cocaine Hydrochloride 0.25 | 1 grain
    Sterilised Water to 100.00 | to 440 minims


    Dissolve the salts in the sterilised water. Zinc chloride does not make a perfectly clear solution with water, but the filmy deposit is not of importance, and no attempt should be made to dissolve it by the addition of acid.
     
  2. Jatelka

    Jatelka Psychedelic Shepherdess Platinum Member & Advisor

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    Gorgeous finds benga: Good to see you's still around
     
  3. Benga

    Benga Platinum Member & Advisor

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    for those of you wondering :

    http://albumen.stanford dot edu/library/monographs/sunbeam/chap45.html


    WEIGHTS AND MEASURES.

    WEIGHTS and capacities in England and France are estimated from certain standard linear measurements. In England, a pendulum vibrating seconds of time in a vacuum, at the latitude of London, and at the level of the sea, is assumed as the standard of linear dimensions; it is 39.1393 inches. This is the standard, too, of all our measurement of length, capacity, and weight in the United States. But, like the English, we retain all the old and arbitrary systems of weights and measures; whereas the French have assumed. a decimal system in all their measurements that merits the highest praise and imitation. The linear standard of the French, from which they derive all other measurements, is called a métre. It is the ten-millionth part of a quarter of the earth's meridian, and measures 39.371 inches. The métre is divisible decimally in both directions.

    The connecting link between the English linear unit and their measures of capacity and weight are as follows:

    A cubic inch of distilled water weighed in air with brass weights at a temperature of 62° Fahr., the barometer standing at 30 inches, is equal to two hundred and fifty-two grains and four hundred and fifty-eight one thousandth parts of a grain; of such grains 5760 are required to make the imperial standard troy or apothecaries; pound; and 7000 of such grains make the commercial or avoirdupois pound. The imperial gallon has a capacity of 277.274 cubic inches; and a gallon of distilled water, as above, weighs 10 pounds avoirdupois, or 70,000 grains.

    The connecting link between the French linear unit and their measures of weight and capacity, are as follows

    A cubic centimétre of distilled water, at its maximum density, at the temperature of 39.5° Fahrenheit, is the unit of weights and is called a gramme, which is divided decimally above and below.

    A cubic decimétre is called a litre, which is the unit of the measures of capacity, and divisible decimally.
    Comparison of Weights and Measures.
    Apothecaries' Weight. French gramme.
    1 grain = 0.0647
    20 grains = 1 scruple = 1.295
    60 grains = 3 scruples = 1 drachm = 3.885
    480 grains = 8 drachms = 1 ounce = 31.08
    5760 grains = 12 ounces = 1 pound = 372.96

    Symbols.

    grain=gr. scruple=. drachm=. ounce=. pound=lb
    Apothecaries' Measure of Capacity. (United States.)60 minims = 1 fluid drachm
    480 minims = 8 fluid drachms = 1 fluid ounce.
    7680 minims = 16 fluid ounces = 1 pint.
    61,440 minims = 8 pints = 1 gallon.

    Avoirdupois Weight. French gramme.
    1 drachm = 1.77
    16 drachms = 1 ounce = 28.328
    16 ounces = 1 pound = 453.25
    112 pounds = 1 hundred weight
    20 hundred weight = 1 ton

    Apothecaries' grains.1 drachm = 27.34375
    1 ounce = 437.5
    1 pound = 7000
    1 hundred weight = 784000
    1 ton. = 15680000

    Apothecaries' ounce = 480 grains
    Avoirdupois ounce = 437.5 grains
    United States pint = 16 fluid ounces
    Imperial or British pint 20 fluid ounces
    United States gallon = 128 fluid ounces = 8 pounds avoirdupois.
    Imperial or British gallon = 160 fluid ounces = 10 pounds avoirdupois



    Weight of Water at 62° and Capacity of:
    Cubic inches.. Grains
    1 gallon (Imperial) = 277.274 = 70000.
    1 gallon (U. S.) = 231.000 = 56000.
    1 quart (Imperial) = 69.318 = 17500.
    1 quart (U. S.) = 57.750 = 14000
    1 pint (Imperial) = 34.659 = 8750
    1 pint (U. S.) = 28.875 = 7000.
    16 fluid ounces = 28.875 = 7000.
    1 fluid ounce = 1.732 = 437.5
    1 fluid drachm = 0.216 = 54.7
    1 minim = 0.0336 = 0.91

    French Measures of Length. English. inches.
    Millimétre = .03937
    Centimètre = .39371
    Decimétre = 3.93708
    Métre = 39.37079
    Décamétre = 393.70788
    Hectométre = 3937.0788
    Kilométre = 39370.788
    Myriamétre = 393707.88


    French Weights Equivalents in Grains.
    Milligramme, .0154
    Centigramme, .1543
    Decigramme, 1.5434
    Gramme, 15.434
    Decagramme, 154.340
    Hectogramme, 1543.402
    Kilogramme, 15434.023
    Myriogramme, 154340.234



    A gramme of water=1 cubic centimétre=15.43 grains=17 minims.

    1000 grammes of water=1 litre=1 kilogramme=15434.023 grains=2 lb. 3.27 oz. French Liquid Measures. Cubic inches. United States Liquid Measures.
    Millilitre, .0610 16.2318 minims.
    Centilitre, .6103 2.7052 fl. drachms.
    Decilitre, 6.1028 3.3816 fl. ounces.
    Litre, 61.028 2.1135 pints.
    Decalitre, 610.280 2.6419 gallons.
    Hectolitre, 6102.80 26.4190 gallons
    Kilolitre, 61028.0 264.1900 gallons
    Myrialitre, 610280 2641.9000 gallons
     
  4. Benga

    Benga Platinum Member & Advisor

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    thanks. I found these a while back when I was looking for my current Grail of sorts : an authentic recipe / procedure of Vin Mariani, with ratios, because what is usually written on the subject ( amount of coca leaves used, if an extract was added or even extracted HCl, to reinforce effects) doesn't really make any sense.
    everything on the subject seems to be pretty imprecise or hypothetical ( unrealistic cocaine concentrations), and most of the articles just refer to this "star product" for its link with the birth of coca-cola (inspiration and somewhat rival to american coca drinks), and the "endorcement" it recieved. Was it really so great or was it just advertising ?
    I've dug up some info since I last posted on this subject some months back, but nothing that is actually precise, especially on the procedure (maceration, distillation, quantity...).
    What I'm trying to look into now are actual 19th century patent pendings for the drink, which should normally include a description of the manufacture process used, and I doubt this is confidential nowadays...
    Was it really just Bordeaux and macerated / distilled coca leaves ? How can that be so great, macerating 100 or 200g of coca leaves in 1 or two liters of Bordeaux, as some obscure paleoalcohologists might have done was not reported to result in the drink of the century...maybe it was just hype, like absinthe... yet with cocaine in the picture, and reported medical uses in codexes, there's probably more to it. I'm pretty sure actual cocaine Hcl was added to the maceration though, as alcohol doesn't pull coca alcaloids that well...
    Yet coca wine recipes ( I found others from a 1930's french codex...) are a good start.

    take care

    b
     
    Last edited: Oct 4, 2006