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Combinations - Benzodiazepines and Antihistamines (Diphenhydramine, Doxylamine, Hydroxyzine)

Discussion in 'Benzodiazepines' started by jackdeth, May 31, 2007.

  1. jackdeth

    jackdeth Newbie

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    SWIM was just wondering if anyone has combined the two or if SWIY would advise against it. SWIM has only started with 20mg of Valium recently, but not had much effect - probably room for higher dosage SWIM is aware...

    SWIM does enjoy the chilled/zoned out feeling from 100mg of Diph, any major risk of using the two at the same time? Thanks.
     
  2. Psych0naut

    Psych0naut Platinum Member

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    Re: Using Valium with Diphenhydramine

    They are both CNS(Central nervous system) depressants, combining them will cause respiratory depression, and in larg doses respiratory failure. Please just stick to one of them, not both, it's a very real risk.
     
  3. jackdeth

    jackdeth Newbie

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    Re: Using Valium with Diphenhydramine

    Thanks, SWIM thought as much, but SWIM wanted to make sure. By the sound of it, Diph doesn't really go well with anything (alcohol even?) and isn't very well regarded. SWIM wonders how much of a gap one would have to allow between use of the two - if SWIM took say 30mg of Valium on Monday would it be OK to use Diph on the weekend? Basically is there still a risk even when the Valium is out of SWIM's system?
     
  4. Psych0naut

    Psych0naut Platinum Member

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    Re: Using Valium with Diphenhydramine

    Well not the risk of combining the two. Valium(diazepam) is the second longest acting benzodiazepine, which can stay in your blood for days, so if SWIY has taken Valium than it would be safes to wait a few days before doing diphenhydramine, though SWIM also disadvices to do diphenhydramine due to it's deliriant effects. If one wants a OTC(over the counter) high, SWIY is better out doing DXM, or in SWIY's case codeine or dihydrocodeine.
     
  5. Politicalchalk

    Politicalchalk Titanium Member

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    Benzodiazepines and Antihistamines

    Hey all. SWIM has been switching off between clonazepam and lorazepam, all legit. prescribed. Doc has even spoke of alprazolam. Still trying to figure what works. Anyways, I read on a different thread that, to potentiate benzos alcohol should not be used, but instead antihistamines. SWIM is currently on hydroxyzine and was wondering was dose might probably be sufficient (from one's own experience) with antihistamines. This is not over the counter, but Rx. SWIM has it prescribed to help with sleep, and has noticed he can handle large amounts of the antihistamine. still experiementing with the others...about 6mg lor and 4mg cloz....actually it's withing my prescribed range.

    Anyways, SWIM would just love some thoughts, fragments, or interjections and the reader's behealf.

    peace.:vibes:
     
  6. piesrtasty

    piesrtasty

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    Safe to combine hydroxyzine(atarax) with Diazepam(valium)

    swim took 20mg of valium and was curious if adding some hydroxyzine into the mix is safe/recreational or if this combo is dangerous...any timely responses would be greatly appreciated!
     
  7. Panthers007

    Panthers007

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    Re: Safe to combine hydroxyzine(atarax) with Diazepam(valium)

    From Wiki:

    "Other contraindications include the administration of hydroxyzine alongside depressants and other compounds which affect the central nervous system, such as narcotics, non-narcotic analgesics and barbiturates, as well as alcohol, and if absolutely necessary, should only administered concomitantly in small doses as any pre-existing grogginess from these substances may be enhanced. If administered in small doses with other substances, such as mentioned, then patients should refrain from using dangerous machinery, motor vehicles or any other practice requiring absolute concentration, in accordance with safety law."

    See article here:

    http://en.wikipedia.org/wiki/Hydroxyzine
     
  8. Politicalchalk

    Politicalchalk Titanium Member

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    Re: Safe to combine hydroxyzine(atarax) with Diazepam(valium)

    Panthers does have a point, however, this is a standard "Be careful when mixing CNS depressants" in general. 1 dep. + 1 dep. = 3 deps.

    Now, Swim has seen in practice hydroxyzine prescribed EXCLUSIVELY for moderately strong opiate painkillers: "Take 2 (Hydroxyzine) with Lortab (hydrocodone/apap)." It does indeed potentiate CNS depressants, and actually is analgesic sparing (helps the analgesic). Its analgesic in it's own right. It has an oddly abundant list of indications, a prominant one which includes anxiolysis -- helping with anxiety. Swim's dog regularly combines Hydroxyzine Pamoate with his daily Lorazepam, and finds some benefit. He does have a wee bit o tolerance to the benzos, and has been on Hydroxyzine about a year. Stay with low doses and the genuia pig won't die, as long as he's familiar with both. Never try for heroic doses, in anything, that's kryptonite. One last note: Atarax (Hydroxyzine Hydrochloride) vs. Vistaril (Hydroxyzine Pamoate). Swim finds the former to be more sedating and the latter more soothing.
     
  9. myocardial infarction

    myocardial infarction Silver Member

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    Alprazolam and Diphenhydramine (Xanax and Benadryl)

    SWIM has been researching for the last 3 hours and hasn't found anything definitive. SWIM is wanting to take 1.5mg of xanax and 450mg of benadryl(diphenhydramine). So far the information that SWIM has found on drugsforum, errowid and google haven't said that it's lethal or anything like that. Any thoughts, experiences or opinions before SWIM tries this?
     
  10. bloot

    bloot Gold Member

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    Re: xanax and benadryl

    SWIM really wouldn't suggest combining these drugs. He doesn't think it would turn out so well. People have such varied effects from recreational doses of diphenhydramine and one really couldn't tell what could happen. SWIM's friends as well as SWIM himself has gotten different effects each time he has used diphenhydramine even at fixed doses. And not just minor differences. Pretty much a COMPLETELY different experience each time.. And a majority of the time it was a very uncomfortable high.
     
  11. Gradient

    Gradient Chem|EB|DMT Staff Member

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    Re: xanax and benadryl

    My chimp strongly seconds that, bloot. While the combination likely wont result in any dangerous receptor-interaction at the described doses, the experience itself might indeed prove to be dangerously disorienting. A deliriant mixed with a benzodiazepine sounds like a great model for induced psychosis, which might be interesting to some, but certainly not pleasant for most - completely convincing delusions with a markedly reduced capability to inhibit the brain's projection of such a false reality. Sounds like bad-news-bears to my chimp.
     
  12. soma

    soma

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    First off, please know that by all accounts (including my own) diphenhydramine in deleriant doses is generically unpleasant. SWIM hated this drug with a passion, and would rather be stabbed in the arm than take it again. Literally.

    Second, as both drugs are depressants, there is always an OD risk, please be mindful of this. There is also a risk of severe delerium, exasperated by alprazolam intoxication. Please use caution if you proceed. If SWIY must do this combo, which SWIM doesn't advise, he suggests reducing the diphenhydramine dose.
     
  13. OsCarwild

    OsCarwild

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    Combining two sedatives like that, especially with such a high dosage of benadryl, sounds like a very good recipe to makes ones heart beat dangerously slow.
     
  14. soma

    soma

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    Dangerously slow? no, high-dose diphenhydramine is a cardio-stimulant, due to its atropine like effects. I would be much more concerned with extreme tachycardia. This is what happened with SWIM, and it was incredibly unpleasant. He knows that benzos can raise HR even more, though are useful in stimulant-induced tachycardia.
     
  15. OsCarwild

    OsCarwild

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    SWIM is sorry, he apparently isn't as informed as Soma. But from his personal experience of taking diphenhydramine sleep meds, and his experience with prescribed clonazepam and valium, he has noticed that they both drastically slow his heart rate. Perhaps it varies by peros
     
  16. Boca Bitch

    Boca Bitch

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    Consider lowering the dose of the diphenhydramine. Benedryl is COMMONLY used off-label recreationally as a 'booster' to alcohol.

    I've yet to hear of an ER case from OD of the combination of both. That said, since both alcohol and benzodiazepines have effect over GABAa, it'd be safe to say that low-dose, there should be little complications.... but chances, SWIY won't remain conscious for the half-life of the both.. as seperately they're incredibly sedating.. combined..... :S
     
  17. lineartransform

    lineartransform Titanium Member

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    If SWIY does this in his house, and stays in his house, you'll likely have a hazy experience that is remembered as nothing too spectacular. You might find some odd things around the house from activities you don't remember doing, etc.

    But good god, if you are out in public or somehow manage to leave the house, you are asking for trouble. The xanax will play with your memory and inhibitions, and the DPH will ruin your ability to tell between what is real and what is fabricated by your brain.

    It's not about "handling" your high, there simply is no ability with this combination. The combination of the fact that it's really not that fun in any way and the risk of idiocy would lead SWIM to not reccommend this.

    I have a feeling you are doing the "hrmmm... what do i have in the medicine cabinet" thing, and it's not always a good idea.
     
  18. myocardial infarction

    myocardial infarction Silver Member

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    Well SWIM decided on trying it that night anyway. SWIM started with 1.5mg xanax and 450mg benadryl. It took about an hour for SWIM to notice anything. Deciding that SWIM was ok she decided to take 150mg more of benadryl. SWIM and her husband drove to the redbox to pick up a movie and on the way home SWIM started feeling happy and sedated. Since SWIMS husband was noticing the effects he decided to take 300 mg benadryl and 1.5mg xanax. SWIM and hubby got into bed and put the movie in to watch. After an hour of watching the movie they were both completely out of it and SWIMS hubby was convinced someone was hiding in the closet lol. They both just fell asleep and slept for a good ten hours. SWIM woke up with her head somewhat cloudy but felt pretty good all around. After an hour of being awake SWIM had a cup of coffee and a 10mg adderall. SWIM aced a medical terminology test then studied for another 5 hours. It was an ok experience but SWIM wouldn't do it again.
     
  19. soma

    soma

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    Glad SWIY made it through alright.. It was a risky combo to say the least, and SWIM is baffled that SWIY found high-dose diphenhydramine enjoyable.
     
  20. myocardial infarction

    myocardial infarction Silver Member

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    Re: Alprazolam and Diphenhydramine (Xanax and Benadryl)

    all the diphenhydramine did was produce small hallucinations. but it mostly made SWIM really drowsy. it wasn't enjoyable or unenjoyable SWIM isn't sure how to describe it. but SWIM kept checking pulse to make sure everything was ok. SWIMs heart rate stayed at the normal 70bpm. no tachycardia, breathing was normal too