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Opinions - best legal replacement for a-pvp USA

Discussion in 'Beta-Ketones' started by JTC3889, Feb 9, 2014.

  1. JTC3889

    JTC3889 Silver Member

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    As you might have seen, I posted a thread that stated that 10 beta-ketones are being temporarily scheduled (1) including a-pvp. I would like to get any feedback on what is still legal that would give that feeling that a-pvp and previously MDPV created, and which can also be vaporized as a salt. Preferably something related to the "PV's" and more distantly perhaps the "pentedrones" as I remember it stated. Any feedback is good feedback.
     
  2. chemman

    chemman Silver Member

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    At the moment, the best replacement for MDPV and a-PVP is a-PHP. On the internet I found information: a-PHP is better than MDPV and PVP.

    Full name alpha-PHP: 1-Phenyl-2-(1-pyrrolidinyl)-1-hexanone

    [​IMG]
     
  3. JTC3889

    JTC3889 Silver Member

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    That is wonderful; forget a-pvp, but it's supposedly better than MDPV, that's remarkable.
    I have one reservation about this compound, however. The para-methylated version of this chemical is MPHP, MPHP can lead to serious poisoning with toxic liver damage and rhabdomyolysis. And since they are only one carbon away from being identical, molecularly, then we must consider this possibility before trying it at least until it is proven, or even until a general consensus is reached among potential users. And if anyone thinks they can find any data on this, post it ASAP! Someone should make a drug info page on a-PHP if it hasn't been done already.
    And last I will say that I am on my knees praying that this stuff is safe, and legit. Otherwise this ban may take a toll on me for a good while, as I am a regular user of a-PVP and if this new stuff doesn't check out, I'm fucked.
     
  4. chemman

    chemman Silver Member

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    According to academic studies, para-methylated derivatives may cause liver failure as a sad side effect, eg. MPHP (MePHP), pyrovalerone, MPPP (MePPP) because of metabolism of these derivatives: the para-methyl functional group is metabolised by cytochrome P450 which leads to toxic metabolites.
    This problem does not apply to derivates without para-methyl group as alpha-PVP, alpha-PPP and alpha-PHP. So I think there's nothing to worry about, Your liver shouldn't suffer that much : )

    More information:

    Peters, FT; Dragan, CA; Kauffels, A; Schwaninger, AE; Zapp, J; Bureik, M; Maurer, HH (2009). "Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis". Journal of analytical toxicology 33 (4): 190–7

    Sauer, C.; Hoffmann, K.; Schimmel, U.; Peters, F. T. (2011). "Acute poisoning involving the pyrrolidinophenone-type designer drug 4′-methyl-alpha-pyrrolidinohexanophenone (MPHP)". Forensic Science International 208 (1–3): e20–e25.
     
    Last edited: Feb 10, 2014
  5. JTC3889

    JTC3889 Silver Member

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    chemman, can you give some more info to support your claim that a-php is both stronger that a-pvp as well as mdpv?
     
    Last edited by a moderator: Apr 12, 2014