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Opinions - Best route for codeine

Discussion in 'Codeine' started by zeno, Aug 31, 2010.

  1. zeno

    zeno Newbie

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    A certain garden gnome who shines my shoes at night possed a question to me - what is the best route for use of codeine? The gnome was curious about experiences or scientific research to make it even better. The gnome point out the following...

    (assuming a CWE for most of these)
    1. Swallow - the standard route, can be modified with variables such as no food in stomach, grapefruit juice, etc.
    2. Up where the sun don't shine - the gnome has used; however, codeine (like any narcotic) creates constipation, creating a lot of traffic jam. Can this be used regularly considering the traffic jam may soak up all the goodies?
    3. IV - everything researched says this is a giant no-no. Extreme histamine reaction to death.
    4. IM - the gnome has tried, didn't really notice a big difference compared to other routes.
    5. SC - see above.
    6. Insufflation - one would need pure codeine; the gnome has not tried.
    7. Smoking - the gnome doesn't think this is possible correct?
     
  2. matchaca

    matchaca Silver Member

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    Swim would stick with the oral way with some cimetidine or grapefruit juice...
     
  3. Babychic01

    Babychic01 Newbie

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    [FONT=Verdana,][SIZE=-1]Codeine is mainly used as a pain reliever, but is also used for the relief of a non-productive cough, and as a anti-diarrheal agent. 120mg of codeine administered SC (subcutaneously, injected under the skin) provides pain relief equal to 10mg of morphine administered by the same route. Doses used to relieve cough or diarrhea range from 5mg to 30mg. [/SIZE]
    [FONT=Verdana,][SIZE=-1]
    [/SIZE]
    [FONT=Verdana,][SIZE=-1]Codeine is absorbed quickly from the GI tract and it's first pass through the liver results in very little loss of the drug. This contrasts with morphine in which over 90% of the drug is metabolized in the first pass through the liver resulting in a considerable loss of potency when administered orally. This is why codeine is a common opiate in the relief of pain, the ease of oral administration. [/SIZE]
    [FONT=Verdana,][SIZE=-1]
    [/SIZE]
    [FONT=Verdana,][SIZE=-1]Codeine can be administered by many routes, this includes, SC, IM (intramuscularly), as an enema, and orally. Note, codeine can't be administered safely by IV (intravenously) injection as it can result in pulmonary edema (fluid in lungs), facial swelling and other life threatening complications. [/SIZE]
    [FONT=Verdana,][SIZE=-1]
    [/SIZE]
    [SIZE=-1][FONT=Verdana,]SWIM has read about a new invention for [/SIZE]Intranasal codeine for the rapid suppression of cough and rapid relief of pain which provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, but is not aware if this is widely available on the market.


    As for smokin codeine .. this is something SWIM has not tried when she was abusing opiates but due to how it is metabolised would imagine it would be a complete waste of time and codeine.



    SWIM thinks purely by how codeine is metabolised that orally is probably the best and safest route of administration.


    Stay safe :thumbsup:
    [FONT=Verdana,][SIZE=-1] [/SIZE]
     
    Last edited by a moderator: Apr 30, 2017
  4. sasafrass

    sasafrass Silver Member

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    Considering its ceiling for effects, compared to morphine, etc. its not much of a rec drug. Good mild pain killer though.
     
  5. erin411

    erin411 Newbie

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    I disagree, for someone with no experience with stronger opiates, codeine can be a great little rec drug now and then, especially if combined with cannabis. Of course, I would never engage in such irresponsible and illegal activities ;)
     
  6. zeno

    zeno Newbie

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    The garden gnome told me that his source of more powerful narcotics has dried up and unfortunately has to go with codeine. He told me codeine is nothing compared with something like oxy; however, still a mild buzz when mixed with a couple drinks.
     
  7. sasafrass

    sasafrass Silver Member

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    Ah, a gateway drug ...
     
  8. Babychic01

    Babychic01 Newbie

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    Yep, unfortunately for SWIM, Codeine did in fact become her "gateway drug" .. it started a long affair with opiates which eventually led onto a full blown heroin addiction for almost 4 years!

    ..

    now and then being the important words here! SWIM very quickly became addicted to Codeine and would urge anyone to be very careful and think long and hard if they are contemplating using this medication for any purpose other than pain relief. Even those of us who are prescribed it regularly/long term for legitimate reasons can find themselves unsuspectingly becoming addicted! It may be described as a drug to manage mild to moderate pain..but its also an addictive painkiller!

    Stay Safe! :thumbsup:
     
    Last edited: Sep 22, 2010
  9. Starr Scream

    Starr Scream Newbie

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    My best friend's dog insists that the most pleasure he has ever had from codeine was in taking around 120mg (using CWE) - eating a corned beef sandwich immediately after consuming the mixture.
    I myself have absolutely no idea how this works (and I don't really believe him), but he is quite vehemently insisting, so there you go.
     
  10. dugg

    dugg Silver Member

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    Swim found orally on an empty stomach with cyclizine most effective.
     
  11. Mint boi

    Mint boi Gold Member

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    The bioavailability of oral codeine is somewhere in the region of 90% so nothing is really going to improve on that much, as far as routes of administration go.

    Something to consider is the fact that codeine is a CyP2d6 inhibitor, so it's going to start to block it's own conversion to morphine after a while therefore SWIM finds it is best to get the full dose through the liver in one go (This inhibition is probably very much dose dependent, might not be as much of an issue with lower doses). Nasal and IM probably (def in the case of nasal) won't be as fast as the GI tract in this respect.

    In Swims experience abstaining from food for a good 3-4 hours then dosing orally has always been the best route. Rectal has always seemed pretty much on par with oral so no point going down south.
     
  12. RoboCodeine7610

    RoboCodeine7610 Silver Member

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    As stated above, codeine itself is a CYP2D6 inhibitor, and swim finds the strongest way by FAR is to take the result of a CWE, and take it on an EMPTY stomach, followed immediately by a just-opened carbonated drink (swim uses diet pepsi).

    Trust swim on this one, he´s used codeine for a very long time and he assures everyone that this is the strongest way by far.

    Robo
     
  13. justinius23

    justinius23 Newbie

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    some good info here. thanks for the advice guys - especially babychic01 ;)