Health - CCC (Coricidin) Health Risks Fact Sheet

Discussion in 'DXM' started by Alfa, Dec 28, 2005.

  1. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    This thread is not for discussion, but only for posting facts about health risks of CCC. All facts must be supported by references. There is no room for personal experience or statements here.
     
    Last edited by a moderator: Sep 3, 2007
  2. polloloco001

    polloloco001 Gold Member

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    Coricidin Cough and Cold or CCC is a cold medication for people with high blood pressure which contains dextromethorphan or DXM. DXM is the only psychoactive ingredient in CCC. CCC does however contain Chlorpheniramine Maleate as an active ingredient. Each CCC tablet contains 30 mg of DXM and 4 mg Chlorpheniramine Maleate. "High doses of Chlorpheniramine Maleate can cause severe and life-threatening symptoms including seizures, loss of consciousness, bleeding from skin, mouth, rectum, and vagina, and possibly death". (http://www.erowid.org/chemicals/dxm/dxm_health.shtml) Although the LD 50 of Chlorpheniramine Maleate is apparently unknown and apparently relatively high, in combination with DXM it is dangerous. "This is an anticholinergic drug, a class of drug which in general is very dangerous to take in large doses with dextromethorphan. Worse yet, chlorpheniramine maleate is also metabolized by the same liver enzyme (known as CYP-2D6) as is DXM. The competition for this limited enzyme by the two drugs makes taking them together, in large doses, a dangerous combination." (http://www.coricidin.org/). "Very large amounts of Coricidin Cough and Cold has caused many dozens of hospitalizations, and several deaths." (http://en.wikipedia.org/wiki/Non-medical_use_of_dextromethorphan#Dangers). There are many sources of DXM which contain no other active ingredients. Many are in tablet or gel cap form and are readily available. A list of dxm only products can be found at http://www.erowid.org/chemicals/dxm/dxm_info2.shtml
     
  3. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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  4. babols

    babols Newbie

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    DXM, a synthetic drug that chemically is similar to morphine, was approved by the Food and Drug Administration as a cough suppressant in 1954. Drug manufacturers began putting it in cough syrups in the 1970s as a replacement for codeine. DXM is sold legally without a prescription because it does not make users high when taken in small doses. The recommended dose, about one-sixth to one-third of an ounce of an extra-strength cough syrup, contains 15 to 30 milligrams of DXM, according to the National Institute on Drug Abuse. At doses of 4 or more ounces of cough syrup, DXM produces effects similar to those of PCP or the anesthetic ketamine, the institute says. DXM can produce hallucinations, depressed breathing, elevated blood pressure and an irregular heartbeat. Overdoses can cause seizures, comas and death. It can be particularly dangerous when taken with other drugs. The federal government does not keep statistics on DXM abuse, but drug specialists say anecdotal evidence suggests that its use does not approach that of methamphetamine or the club drug Ecstasy. DXM abusers, drug specialists say, typically are young teens who are seeking a cheap alternative to drugs that are more expensive and more difficult to get. (http://www.psycport.com/stories/usatoday_2003_12_29_eng-usatoday_news3_eng-usatoday_news3_052159_329386689756834699.xml.html)
     
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  5. Phungushead

    Phungushead Twisted Depiction Staff Member Administrator

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    Chlorpheniramine Maleate is an antihistamine, but it has anticholinergic
    effects.

    Anticholinergics block the effects of acetylcholine in the body which is
    responsible for some of the nervous center's activities. Some effects are
    lowered stomach acid secretion, slower movement of food through the
    digestive system, less perspiration, less salivation (cottonmouth), and
    increase in heart rate and blood pressure.
     
  6. pharmapsyche

    pharmapsyche AKA Miss Methylene Titanium Member

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  7. Kcaj

    Kcaj Silver Member

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    You could look up the definition of those two terms and determine that rather easily.

    More on topic, however, is something I am going to say that may cause a bit of a stir.

    Many experienced psychonauts have often mixed DXM with other antihsitamines (particuarly Benadryl, which contains diphenhydramine).

    This generally helps with nausea and itching... "robo-itch".

    Anyone coming here should know, you can also get massively fucked up on diphenhydramine. It causes you to "trip balls", lots of OEV and generally effects that seem like they'd go well with DXM and weed.

    Mixing the two substances is VERY dangerous! Its bad enough for your health that youcan literally FEEL the harm you are causing to your body when you fuck up the dosages.

    I've done it myself on several occasions, experimenting to find the appropriate levels of DXM and diphenhydramine to have an enjoyable experience. The results are too varied even at similar dosages to really come to a strong conclusion, but from the start, I knew something was there.

    Like most of you, I heard first about DXM from a few friends, and then read a lot about it online. Because of my pre-tripping research, I'd always known not to take CCC, and had read all the horror stories.

    This may seem far-fetched, but I've long been a believer that products like DexAlone, Tussin Clear (no sorbitol, sugars, dyes, etc.), Zicam/max/nite etc. where possibly created with abuse in mind, or atleast somewhere in the back of someone's mind. The reinforcement of such crazy theories came when I decided to give CCC a shot.

    The first time ,I did a box. The synergy olf the CPM and DXM was pretty amazing, it was what I'd been trying to do with diph and DXM for several months unsuccessfully. Made me wonder if possibly the combination was intentional as well as the doses.

    Who knows! Anyway, its unlikely and pretty far out there to begin with.

    <3
     
  8. Richard_smoker

    Richard_smoker Gold Member

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    Pharmapsyche, I know I might be a little late in posting this information, but I would dare say that MOST of the early-generation anti-histamines are also anti-cholinergic. Just think of drugs that are all in the same basic class but have many different effects (besides simple histamine-antagonism)--you've got diphenhydramine, thorazine, Dimenhydrinate, chloramphinerate, compazine (i think that's one...), phenergan, etc. etc.)... you actually run the full range of sleep-inducing, sedating, anti-emetic, anti-itch/anti-histamine. Diphenhydramine is actually even useful in treating PARKINSON'S DISEASE!! (be ya didn't know that!)

    It is the newer 2nd and 3rd generation anti-histamines that are actually specific to certain types of histamine receptors--allegra, loratadine (alavert, claritin). These don't cause the same sedation associated with 1st generation anti-histamines such as benadryl.
     
  9. eche05

    eche05

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    Chlorpheniramine Maleate, besides posing various obvious health risks, inhibits cytochrome P450 which is why coricidin cough and cold experiences may seem "...dirty" or "more intense". Chlorpheniramine Maleate also potentiates and elongates the effects of the alkaloid caffeine.
     
  10. Captain Colon

    Captain Colon Newbie

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    All first-generation antihistamines that I know of exhibit anticholinergic effects, although some types are weaker in that regard than others. Many of them are also 5-HT agonists and have mild SSRI activity...the first SSRIs were derived from antihistamines. Fluoxetine, one of the most widely-prescribed antidepressants today, was derived from compounds specifically selected for their similarity to Diphenhydramine.

    What makes CPM dangerous is its unusually long half-life; 21+ hours compared to 2-8 hours for the more common Diphenhydramine. While this is ideal for use in night-time cough/cold preparations, it is not such a great thing when chowing down on a pack of CCC. You may have noticed that they are sometimes more drowsy than normal for up to a few days after a CCC trip; that's why. As was said, CPM (along with all first-gen antihistamines IIRC) inhibits cytochrome P450, which also happens to metabolize both DXM and CPM, along with the majority of thingsyou put in your body. If, for some reason, You decides to trip on CCC multiple times in a short timespan, the dose of CPM that gave them no problems before may well be fatal the second or third time.
     
  11. LunarSpider

    LunarSpider Newbie

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    Bottom line don't take ccc's, its not worth the risk and there are plenty of safer options to choose from.
     
  12. DoMinya

    DoMinya Newbie

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    Coricidin is bad news. Stick to the dxm. Had a friend addicted to the shit and was air lifted out with seizures on 2 occasions. There is other shit then "robo-tripping"
     
  13. HamsterQueen

    HamsterQueen Silver Member

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    When I was 16 (and stupid) I took a BOX AND A HALF of Coricidin HPB and all I remember is being extremely intoxicated, losing consciousness, waking up, and vomiting my guts out. I'm shocked I didn't die. If I hadn't vomited, I probably would have died. My parents didn't even notice.
     
  14. mer kaba

    mer kaba Silver Member

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    I walked in on my friend who had just overdosed on ccc's and alcohol, I held her blue body in my arms. Luckily it was new years (many years ago) and the EMTs were able to get there in time.
    Something like that you never forget. ccc's are garbage.
    Anyone considering taking them for a DXM high please take what's being said in this thread seriously, it's not an exaggeration.

    (I should have read your OP completely, I saw the personal experience type reports above and figured I'd give mine)
     
    Last edited: Apr 3, 2015
  15. Mr. Finklewoort

    Mr. Finklewoort Silver Member

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    I've had 2 overdoses from CPM, it is in no way safe to be taking at all it can cause rhabdomylosis, seizures, and other things that are horrible for your body.
     
  16. herpeslip

    herpeslip Newbie

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    Read the death report. Still believe Triple C use is over hyped. I have searched tirelessly for adult deaths and my efforts were null.

    It is more dangerous than products containing only dxm. But I still don't see enough postmortem evidence to brand it as many have despite a handful of teenage deaths

    If someone could please show me toxicology reports directly linking adults to Coricidin Cough & Cold deaths, that would be greatly appreciated.