1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    Dismiss Notice


Discussion in 'Drug Articles' started by NeuroChi, Apr 12, 2012.

  1. NeuroChi

    NeuroChi is not his mind Staff Member

    Reputation Points:
    Dec 18, 2007
    Male from earth
    Clonidine is a drug that acts as an alpha-2 adrenergic agonist, the main effect being lowering blood pressure because it decreases the release of norepinephine and epinephrine (adrenalin). It is prescribed for people with high blood pressure, as well as being the main pharmacological remedy for opioid withdrawal due to its effects on the central nervous system. It helps alleviate some of the physical withdrawal symptoms such as excessive sweating and hot/cold flashes.

    [h="1"]Introduction to [VAR]PAGENAME[/VAR][/h]

    [h="1"]Using [VAR]PAGENAME[/VAR][/h]
    Clonidine can be taken orally as prescribed for high blood pressure. Its use has also been reported in shaving soaps.

    [h="2"]Ways of Administration[/h]
    [h="3"]Taking [VAR]PAGENAME[/VAR] Orally[/h]

    [h="3"]Snorting [VAR]PAGENAME[/VAR][/h]

    [h="3"]Injecting [VAR]PAGENAME[/VAR][/h]

    [h="3"]Plugging [VAR]PAGENAME[/VAR][/h]

    [h="2"]Effects of [VAR]PAGENAME[/VAR] [/h]
    Clonidine lowers blood pressure and eases symptoms of opioid withdrawal such as hot/cold flashes and excessive sweating. Clonidine can make the user drowsy or sleepy, and these effects are more prominent if clonidine is injected. Clonidine can have some anxiolytic (anxiety reducing) effects as well by relaxing the body.

    [h="2"]Combinations with [VAR]PAGENAME[/VAR][/h]

    [h="2"]Different Uses for [VAR]PAGENAME[/VAR][/h]

    [h="1"]Pharmacology of [VAR]PAGENAME[/VAR][/h]
    Clonidine is an alpha-2 adrenergic agonist. Activation of these receptors decreases release of norepinephrine and epinephrine. Clonidine lowers blood pressure.

    LD[sub]50[/sub] (mg/kg) (as the hydrochloride) [1] :
    Mice : 328 orally, 18 intravenously
    Rat : 270 orally, 29 intravenously

    [h="1"]Chemistry of [VAR]PAGENAME[/VAR][/h]

    Column 1 Column 2
    0 Systematic (IUPAC) name: N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
    1 Synonyms: 2-(2,6-dichloroanilino)-2-imidazoline, 2,6-dichloro-N-2-imidazolidinylidenebenzenamine, 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2), 2-[(2,6-dichlorophenyl)-imino]-2-imidazoline; ST-155, Catapres, Catapressan, Clonistada, Dixarit, Duraclon, Isoglaucon, Paracefan (hydrochloride)
    2 Molecular Formula: C[sub]9[/sub]H[sub]9[/sub]Cl[sub]2[/sub]N[sub]3[/sub], C[sub]9[/sub]H[sub]9[/sub]Cl[sub]2[/sub]N[sub]3[/sub].HCl
    3 Molar mass: 230.09 g/mol, 266.55 g/mol (hydrochloride)
    4 CAS Registry Number: 4205-90-7, 4205-91-8 (hydrochloride)
    5 Melting Point: 130°C, 305°C (hydrochloride)
    6 Boiling Point: no data
    7 Flash Point: no data
    8 Solubility: Freebase freely soluble in methanol, alcohol; Hydrochloride 1 g dissolves in 6 mL water (60°C), about 13 mL water (20°C), about 5.8 mL methanol, about 25 mL ethanol, about 5000 mL chloroform; soluble in absolute ethanol; slightly soluble in chloroform; practically insoluble in ether
    9 Additionnal data: none
    10 Notes: Freebase aspect : white to almost white crystals

    [h="1"]The Dangers of [VAR]PAGENAME[/VAR][/h]
    [H="2"]Danger 1[/H]
    [H="2"]Danger 2[/H]
    [H="2"]Danger 3[/H]
    [H="2"]Danger 4[/H]

    [h="1"]Producing [VAR]PAGENAME[/VAR][/h]

    [h="1"]Forms of [VAR]PAGENAME[/VAR][/h]
    Clonidine is available in 100 mcg tabs.

    [h="1"]Legal Status of [VAR]PAGENAME[/VAR][/h]

    [h="2"]United Nations[/h]



    [h="2"]Other Countries[/h]

    [h="1"]History of [VAR]PAGENAME[/VAR][/h]

    [H="2"]Popularity of [VAR]PAGENAME[/VAR] over time[/H]

    [h="1"]More [VAR]PAGENAME[/VAR] Sections[/h]
    Drug info - Clonidine
    Drug info - Clonidine as a recreational drug?

    Clonidine for opiate withdrawals

    [h="1"]The Latest [VAR]PAGENAME[/VAR] Threads[/h]


    [CAT]Alpha2-adrenergic receptor agonist[/CAT] [CAT]Imidazoline receptor agonist[/CAT]
    [CAT]Antihypertensive[/CAT] [CAT]analgesic for neuropathic pain[/CAT]

    [1]Merck Index, fifteenth edition (2013)

    Attached Files: