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Cocaine- Can't find a straight answer

Discussion in 'Drug testing discussion' started by nik12937, Dec 16, 2010.

  1. nik12937

    nik12937 Silver Member

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    Well fellow SWIMmers, SWIM has a god question that he couldn't get a solid answer from by using Google or the search engine.

    SWIM weighs nothing, like, 150lbs. And he has a relatively fast metabolism. If SWIM did let's say, .25g of cocaine (.5 split between two people), first time he ever used, last time he will for a while, how long would anyone estimate that it would take until he can pass a home drug test, not a lab one.

    SWIM has heard cocaine is out of your system from infrequent use within 3 days, but that's cocaine, not its metabolite (which SWIM can't remember the name of). The metabolite is what SWIM is wondering about because that's what tests look for, and he can't seem to find how long it takes before it's eliminated from your body.

    Does anyone have an idea?
     
  2. Moving Pictures

    Moving Pictures Titanium Member

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    The cocaine is metabalized into the metabolite (can't think of the name eiter). Actual cocaine doesn't stay in your system for up to 3-5 days, the metabolite does.

    Okay here's a thing from erowid (take it for what you want):

    That was the second answer on google so I don't know what you're talking about not finding anything. This info is also in Jasim's drug testing guide. When one is talking about how long they will test positive for cocaine, they mean how long they will test positive for it's metabilate.
     
  3. Mr. Jiki

    Mr. Jiki Titanium Member Donating Member

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    MovingPictures is correct, the screen is going to test for cocaine metabolites, specifically benzoylecognine (BE) at 300 ng/mL. Cocaine half-life does not seem to be dose dependent unless the dose is an abnormally high dose. BE will be detectable in plasma within 15-30 minutes of administration, regardless of route of administration.

    BE half-life also depends on the route of administration. The literature shows that the BE half-life of intravenous administration, smoking and inhalation as 347 (5.78 hrs), 324 (5.4 hrs) and 213 (3.55 hrs) minutes, respectively.

    As we don't know SWIYs route of administration, it would be prudent to say that SWIYs urinary BE levels could be detectable for ~2.5 days. As SWIY should know from reading Jasim's drug testing guide, at home urine immunoassays are notoriously unreliable.

    **Bonus for chronic Cocaine users** The above numbers would not apply for prolonged IV administrations. Urinary half-life times would decrease for cocaine, BE and ecognine methyl ester to 0.8, 4.5 and 3.1 respectively. Take note, increased plasma protein binding of cocaine can extend BE detection times seen in high dose, chronic users.
     
    Last edited: Dec 16, 2010
  4. Killa Weigha

    Killa Weigha Newbie

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    If only that were possible we'd all be saved so much consternation.

    Really, that's a question one should know the answer BEFORE they snort coke, no? Is you Mom gonna piss test you for real? WTF?
     
  5. nik12937

    nik12937 Silver Member

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    SWIM meant to say good question, I'm not sure how he didn't catch that^...

    And also, the ROA would be through sniffing or snorting, same thing, SWIM must be a bit slow today or something...

    And MovingPictures, I saw that result, but the wording really confused me, because the question involved the metabolite and cocaine, but the answer only provided how long cocaine would stay, it didn't really touch upon Benzoyl-ecgonine, but maybe it was meant to be taken that way...

    So about 3 days give or take a few? SWIM would wait a week to be sure. And SWIM is temporarily living with his parents because of a financial situation, so that's why it's a home test.
     
  6. Mr. Jiki

    Mr. Jiki Titanium Member Donating Member

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    SWIYs BE urine levels should be undetectable using a "dipstick" test in ~1.5 days at the ROA and dosage stated. 3 days will be more than enough time if SWIY is paranoid about having a presumptive positive. 1 week is overkill. SWIY should abstain from substances not approved by SWIYs parents for the duration of SWIYs stay to avoid future situations like this.
     
  7. User-126494

    User-126494 Newbie

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    There's lots of good information here: Drug Testing - A Comprehensive Guide

    Benzoylecgonine is the primary metabolite tested for and has a half lfe of 6-8 hours depending on a number of metabolic factors, including polydrug use such as alcohol. It has a half life of approximately 6 hours. Alcohol and other drugs will also occupy the liver and cause for slower metabolism of all drugs in the system.

    A lot of the cocaine will be passed by the renal system and excreted in the urine, but this may be sped up by acidification of the body with something like cranberry juice, which is also a natural diuretic which will increase urination. The effect of this may be small, but it's better than nothing.

    Mr. Hamster isn't sure, but it appears that the cocaethylene is metabolized into benzoylecgonine, or at least it appears to in some animal studies done in this paper which is in the DF Document Archives:

    Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterase (2003)

    That would mean that in addition to clearing the cocaine which is metabolized directly into benzoylecgonine, one would have to wait an additional 6-8 hours for the cocaethylene to be metabolized into benzoylecgonine which would then have a half life of about 6 hours as well.

    It's a fairly complicated thing to calculate exactly how much and how fast it will be eliminated from the body. But, as SWIMr.Jiki points out, one can easily calculate the elimination half life and get a pretty fair estimate. Also, with chronic use, it might take longer for elimination, but with a consistent long-term dose administration a maximum plasma level is built up and then it's a matter of just clearing that, which could take several days, or more than a week depending on all the factors involved.

    If it were insufflated, then some might be caught in the mucosa and be released slowly over a period of days. But then again, that depends on the condition of the sinuses and the characteristics of the mucosa. Complicated.

    Mr. Hamster says, it's complicated, however as outside guess, the hamster would say that after 2-3 days one could be relatively safe to pass.

    Be well..
     
  8. ScorpioSunshine

    ScorpioSunshine Newbie

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    There have been good answers already given, so I will just add some anecdotal evidence:

    When Ex-Man and his female sidekick were using, Ex-Man had to take court-mandated drug UAs.

    He passed every single test, waiting four days between using cocaine and testing, with one exception where he waited 3 days and still passed.

    While it is possible to go too long (as someone stated --overkill), perhaps if it's very important that swiy pass this test, it's better to either:

    A. Abstain

    or

    B. Better play safe than sorry -- either wait the longest time stated in this post or the posts above/the info presented, or split the difference. Basically, use a good mixture of science and common sense. ;)

    (When in doubt, go with the science ..)
     
  9. Jasim

    Jasim Gold Member

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    The metabolite of cocaine is benzoylecgonine as stated above. Detection times listed for drugs typically include both the parent drug and any tested metabolites. That is the case in the Drug Testing Guide. Where it says that a drug has a detection time of so many days, that means that is the detection time of the parent and any metabolites that are tested for. 3-4 days should be enough time for cocaine and benzoylecgonine to clear the system.
     
  10. nik12937

    nik12937 Silver Member

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    Ah, SWIM forgot about that, he'll make sure to use a bit of saline spray or similar to clear his nostrils.

    And thanks for all the tips guys (and/or girls), his test isn't for a few days still so he should be just fine :)

    And SWIM will also take a break from drugs until he's moved out, he just didn't forsee having to move back in temporarily:laugh: