[Drugs-Forum note: Factual errors are contained in this post. Grapefruit juice does not affect CYP2D6 activity. See this thread for more information.] This post is for those wishing to get the most out of any Codeine available to them. This has no doubt been posted before, and is well-known information, but I'd like to point out the advantages/disadvantages associated with each method of potentiation. First off, Codeine is - in every sense of the word - a weak opiate. This is determined by a number of factors:- 1. The Side Effects Okay, this is probably the most obvious of all. Yes, the use of Codeine at recreational doses brings with it some nasty side effects. Namely: The Opiate Itch: Due to Codeine's analgesic qualities, scratching probably won't help. Shortness of breath: This is caused by large doses of Codeine slowing down the respiratory process. Other side-effects: These vary between individuals. As this is not the focus of this post, I won't go into any further detail. 2. Dosage Issues The majority of Codeine's recreational properties are noticed due to it being metabolised into Morphine in the body: Conversion into Morphine: There appears to be a ceiling to the amount converted. The conversion is approx 100% Codeine = 10% Morphine. Availability of the drug: This varies greatly between countries. As an example, in the UK Codeine is available upto 8mg without prescription. With prescription, Codeine is available upto 30mg. The amount of tablets needed to obtain a recreational dosage can run into hundreds. Anyway, back to the topic in hand... CODEINE POTENTIATION. Aww, crap. Unfortunately something important has come up and I now have to leave my computer. I shall post this as it is. Don't bother replying I will complete the writing in another post later today. Apologies for a useless post so far.