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Cold Environments and MDMA

Discussion in 'Ecstasy & MDMA' started by red_LED, Apr 2, 2007.

  1. red_LED

    red_LED Newbie

    Reputation Points:
    Dec 11, 2006
    SWIM noticed that literally on ANY drug the high could be lessened/abolished by simply being in a cold environment (outside during winter, windy conditions, etc). I was wondering how many other swims find that cold environments affect their MDMA experience?

    Last night I was the beach thizzin/rolling with friends. In northern california the beaches are still a little chilly and windy post sunset. Anyway, SWIM barely had a mind-high, let alone a body high, however, several hours afterwards My friends and I returned to a warm house and was instantly feeling the experience. In fact, SWIM popped another pill and began peaking 30 minutes afterwards (spent 3 hours at the beach with no peak). SWIM noticed this effect on a few other chilly nights he happened to be popping pills on.

    The thoughts of other members? Is this unfortunate symptom due to nerves throughout the body getting chilly and numb?
  2. namooP


    Reputation Points:
    Feb 4, 2007
    Its best not to come up in a cold environment, or remain in one for too long. Last night, I had an enjoyable experience (the proceeding colazepam accounts for his poor spelling and grammer). 90% of the time was spend in a nice warm room. Towards in the end of the night though, the heat became too much so SwiM and a girl went down to the bathroom to chillout for a little while, which was lovely. Cool air, warm bodies, perfection.
  3. Nnizzle

    Nnizzle Gold Member

    Reputation Points:
    Oct 4, 2007
    28 y/o from earth
    I would ask namooP to provide a source for his suggestion to not come up in cold environments but he hasn't posted for three years. Does anyone have experience with this? Comments? Literature? It's possible cold weather could affect the experience, as body temperature is affected by MDMA ingestion. Hyperthermia has also been shown to enhance toxicity, perhaps being in a cold environment is actually a good idea?
  4. godztear

    godztear Silver Member

    Reputation Points:
    Nov 5, 2009
    31 y/o from Minnesota, U.S.A.
    Slap my monkey and call him silly but he says that one of the best feelings while rolling is the cold weather with a nice fluffy winter coat in a car going down the interstate, techno thumping with the subwoofers.
  5. Dr. Satan

    Dr. Satan Palladium Member

    Reputation Points:
    Jul 8, 2009
    from earth
    Compared kinetics effects of MDMA in animals allowed to exclude certain cause and effect relationship between some parameters. It was possible to show that hyperthermia provoked by MDMA did not result from an increase of the body activity, but depended on the ambient temperature.
    MDMA (5 to 7 mg/kg) produces hyperthermia in rat when this one is placed in an ambient temperature of 24°C. When the animal is placed in an ambient temperature of 11°C, MDMA provokes on the contrary hypothermia. In both cases, MDMA entails a locomotive hyperactivity.

    According to the dose of MDMA (10 mg/kg and below), hyperthermia can be preceded by hypothermia. This hypothermia would result from a stimulation of the 5-HT1A receivers, and after desensitization of these receivers, the increase of the 5-HT neurotransmission would entail hyperthermia provoked by the stimulation of the 5-HT2 receivers. It was also suggested that females were more sensitive to the hyperthermal effects of MDMA than males.

    The neurotoxicity of MDMA seems linked to the rise of the temperature which it entails. Indeed, hypothermia provoked by diverse methods has a neuroprotective effect towards MDMA.
    So, a reduction of the ambient temperature - 6°C prevents the action of MDMA on the brain concentrations of tryptophan hydroxylase (enzyme of synthesis of 5-HT).
    Hypothermia alone does not modify the tryptophan hydroxylase concentrations. The hypothesis envisaged to explain these effects is that hypothermia, by decreasing the metabolism, reduces the production of free radicals. In favour of this hypothesis, the administration of free radicals antagonist (N-ter-butyl-aphenyltrone) prevents the effects of MDMA on the tryptophan hydroxylase, but does not act any more if the ambient temperature is increased.
  6. avcpl

    avcpl Silver Member

    Reputation Points:
    Feb 18, 2010
    from U.S.A.
    My friend unfortunately when he takes mdma an environment that is normally comfortable for him (say 75 degrees F) feels very cold to him when he's rolling and it lessens the experience.

    He feels better when it's about 82-84 degrees F. He sweats but drinks sports drinks and water and takes anti-oxidants and he does not dance around so he hopes that isn't doing too much damage?
  7. WillowOne

    WillowOne Titanium Member

    Reputation Points:
    Nov 19, 2009
    from U.S.A.
    SWIM's parrot does not have literature to back any of this up, so it's purely anecdotal at this point. However, the parrot has a tremendously hard time thermoregulating while rolling. Specifically, she becomes excessively cold throughout the entire roll regardless of the ambient temperature.

    On a subzero, January night, she walked several blocks to her house to check on her pets just after the peak of the roll. During the walk, which lasted only 5 minutes or so, the roll appeared to completely end in the cold and she was disappointed. However, as soon as she entered her home and the warm wash of air from the heater came over her, the roll started again in earnest - in fact, she's convinced she began peaking again.

    Temperature seems to be an important variant in the use of MDxx. The Parrot had read the studies posted by Dr. Satan previously as well as studies linking ambient temperature to neurotoxicity. Although the results were somewhat sketchy, the Parrot still chooses to roll in cool environments in case there is a link between neurotoxicity and ambient temperature. However, because she's cold regardless, she doesn't think the temperature surrounding her would make a huge difference.
  8. Toka

    Toka Newbie

    Reputation Points:
    Jun 23, 2010
    from U.S.A.
    In Swim's experience with mdma(pill). Body regulation temperature is greatly enhanced outdoors so much that it interrupts swims high( when its cold/windy). He try's to stay indoors while on mdma now.