I haven't been able to find many reports on combining cannabis and 5-HTP. He has tried this combination a couple of times and noticed quite a different effect from smoking cannabis alone. The first time he took 100mg of 5-HTP and one hour later smoked a single bowl of cannabis. The effects came on as usual, but a couple of minutes later the effects increased to a point that was rather unpleasant. The effects were much more psychedelic than just cannabis alone. It felt like I had smoked much more cannabis then he actually had. He was rather surprised and taken back by the strong effects and instantly fell into a panic attack. After an hour or so the effects subsided a bit and he burnt out as usual. The second time was actually an accident. He had taken 100mg of 5-HTP at lunch because he was kind of in a bad mood and needed a boost. Later that night, approximately 6 hours later or so, he smoked some high quality honey oil (no more than usual) and experienced almost exactly the same effects as the first time. I am interested in hearing if You has ever tried this combination and can add a report here. He has searched through Erowid, but has only been able to find a couple reports, most of which state the same effects experienced by me.