1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.

DHC & grapefruit question

Discussion in 'Opiates & Opioids' started by thealexcometh, Apr 9, 2007.

  1. thealexcometh

    thealexcometh Newbie

    Reputation Points:
    Feb 25, 2007
    from U.S.A.
    since it is so similar to codeine, would dihydrocodeine also be "made weaker" by grapefruite juice or would this work as a potentiation method. Swim seems to remember reading that despite their similarity, DHC functions a little differently. Anybody know?
  2. ironmics

    ironmics Silver Member

    Reputation Points:
    Aug 26, 2006
    32 y/o from U.S.A.
    Re: DHC question........

    DHC is not metabolized into any active compounds so it is different than codeine. Whether or not it's metabolized by 3A4 I do not know though. By the way grapefruit juice does not make codeine weaker. It's pretty unclear whether it does anything good or bad at all. In swim's experience and my research that it does not weaken it though.