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Drug info - Diphenoxylate

Discussion in 'Opiates & Opioids' started by magic_johnson, Jul 26, 2006.

  1. magic_johnson

    magic_johnson Newbie

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    is it possible to abuse diphenoxylate? (lomotil)

    I was prescribed lomotil for after having diharrhea for about a week. I found out that it contains diphenoxylate which is related to some narcotics such as morphine. To prevent abuse they add atropine to cause unpleasant effects. So I was just wondering if anybody has ever used this drug to get high and if so, is it possible to do a cold water extraction to get the atropine out?
     
  2. Fantasian

    Fantasian

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    Diphenoxylate is potentially a recreational opiate and can be used as such, however when combined with Atropine as is the case in Lomotil when taken in high doses the following adverse effects occur. Diphenoxylate is chemically similar to Pethidine (AKA Demerol)

    ventricular fibrillation, supraventricular or ventricular tachycardia, giddiness, nausea, blurred vision, loss of balance, dilated pupils, photophobia, and possibly, confusion, hallucinations and excitation. These latter effects are due to the fact that atropine is able to cross the blood-brain barrier. Because of the hallucinogenic properties, some have used the drug recreationally, though this is very dangerous.

    The recreational effects of Atropine are similar to using large amount of any of the other anti-chlolegenic drugs that act as deliriants. It should be warned that using these drug for recreational purposes can possibly induce Terrifying realistic Nightmarelike hallucinations.


    As to a CWE im not sure and someone else may be able to answer this. FOrtunatly for SWIF he has very easy access to hospital opiates therefore very rarely uses CWE for anything as he can obtain the pure form. If you want to try the CWE and see if it has worked start with a clinical dose and work your way up, the effects of the Atropine should become very obvious even at slightly above clinical dosages without providing too much discomfort or danger.

    These effect most prodominantly observed will be blurred vision.
     
  3. Forthesevenlakes

    Forthesevenlakes

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    also do a search for the "loperamide: sudafed of opiates" thread...if lotamil doesnt readily cross the blood brain barrier there's a few ideas in that thread which might help things work after swiy has done an extraction. great first post.
     
  4. magic_johnson

    magic_johnson Newbie

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    does anyone know the solubility of diphenoxylate or if a CWE would get the atropine out?

    the fact that diphenoxylate is similar to Meperidine makes me want to try this with atropine
     
  5. Nagognog2

    Nagognog2

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    Atropine Sulfate, the usual medical form of atropine, is very soluble in water - 1 gram dissolves in .4ml of H2O.
     
  6. magic_johnson

    magic_johnson Newbie

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    thanks for the info

    do you know if diphenoxylate is soluble in water?
     
    Last edited by a moderator: Apr 29, 2016
  7. Nagognog2

    Nagognog2

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    Very slightly soluble in water, so if a monkey had access to extremely fine filter paper, a Buchner funnel, and a vacuum source - it could work. Other wise the monkey should figure that anything over 2mg (milligrams) of atropine will show toxic effects.

    Read: Save 'em for when you eat at the cheap place down the street with the cook named Sticky.
     
  8. deekyleeky

    deekyleeky Newbie

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    SWIM has an opiate he never heard of....

    SWIM found pills and identified them as diphenoxylate, and atropine, can swim takw a few and get same effects as talking a few percocets? Smoke it? chew? snort? swim would like to know if this drug is at all any good.
     
  9. Abrad

    Abrad R.I.P.

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    Re: SWIM has an opiate he never heard of....

    The atropine content makes this medicine unsuitable for recreational use. Stick to the recommended dose.
     
  10. deekyleeky

    deekyleeky Newbie

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    Re: SWIM has an opiate he never heard of....

    well do any swims out there know how SWim could remove the atropine? and if there is a way to sepwerate the 2 substanced, how much would I want to take and what drugs does it resemble most i.e. codein hydro oxy etc....
     
  11. deekyleeky

    deekyleeky Newbie

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    Re: SWIM has an opiate he never heard of....

    What I really meant to say was how much would swim
     
    Last edited by a moderator: Apr 29, 2016
  12. pinokio

    pinokio Newbie

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    REASEC (Diphenoxylate) recreational potential

    Hello again, dear science rats:).


    SWiM (not me for sure) would like to gather any information regarding to possible recreational use of REASEC (Diphenoxylate) which is an opioid agonist. He is interested in especially:

    1) possibility of recreational use

    2) the (recreational) dose

    3) May the combination with 1-2 beers be harmful? (However alc. potentiates itss effect.)


    SWiM is thankful for any answers.

    pinokio added 1 Minutes and 52 Seconds later...

    EDIT:

    *however=since

    pinokio added 78 Minutes and 2 Seconds later...

    EDIT2: 1 tab contains -> 2.5 mg of Diphenoxylate) and 0.025mg of Atropin.
     
    Last edited: Jun 2, 2008
  13. davestate

    davestate Gold Member

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    Re: REASEC (Diphenoxylate) recreational potential

    I think you mean atropine, which is a very nasty substance to be dealing with, think high heart rate and nausea. Not sure what doses would produce the nasty side effects, but I'm sure some one can answer that. Diphenoxylate seems to be similar to pethidine so it should have abuse potential, however as atropine can be fatal, wait untill someone else gives you safe dosage levels
     
  14. pinokio

    pinokio Newbie

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    Re: REASEC (Diphenoxylate) recreational potential

    Yep it is similiar to pethidine, and yes SWIM meant Atropine, sorry.

    SWIM has done a little research meanwhile and has found out that 50mg of Diphenoxylate can get "extremely pleasurable opiate-like buzz", however, it also includes 0.5mg of Atropine, but it certainly isn't a fatal dose. Though, the lab rat has been already given the dose (47.5mg D / 0.475mg A).

    SWIM is thankful for your reply.

    pinokio added 3 Minutes and 23 Seconds later...

    The ability of Atropine crossing the blood-brain barrier causes the side effects.
     
    Last edited: Jun 2, 2008
  15. davestate

    davestate Gold Member

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    Re: REASEC (Diphenoxylate) recreational potential

    I said how big the dose was not how it causeed the effects :laugh:

    A trip report would certianly be very useful in this instance :thumbsup:
     
  16. pinokio

    pinokio Newbie

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    Re: REASEC (Diphenoxylate) recreational potential

    Ah SWIM is sorry again, misread the thing. The lab rat has been administred the substance at cca 22:00, the effects are said to kick in about T + 02 hours.


    The rat will post the feedback for sure (if he survies:)).

    pinokio added 187 Minutes and 50 Seconds later...

    The report:
    The lab rat has taken 19 pills of REASEC (Diphenoxylate). (cca50mg) and 0.5mg Atropin
    0 Tolerance to opoids.

    Two hours after ingestion, the rat felt something, but only a very mild opiate feeling. So the rat was given 2 pints of bear, and it went from mild to a lil. more mild, however nothing what would worth the Atropine danger. The ammount of Atropine was 0.5g -> rat didn't feel any effect of it.

    Comclusion SWIM can say, diphenoxylate is just not usable for recreational purposes.
     
    Last edited: Jun 3, 2008
  17. Panthers007

    Panthers007

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    Re: REASEC (Diphenoxylate) recreational potential

    If each tablet contained .5mg atropine, and SWIM took 19 tablets, SWIM has taken 9.5mg of atropine. This is a toxic level! Cease & desist at once! 10mg of atropine is enough to cause profound toxic effects in the common SWIM. even 4.75mg is enough to cause toxic effects such as blurred vision, flushed skin, cotton-mouth to beat all, and other nasties. 10mg may cause hallucinations of the deleriant variety - seeing things that aren't there which SWIM believes truly are.

    Diphenoxylate can/will cause a narcotic high in large amounts. But with that level of atropine it is plainly not worth it. Save 'em for their intended use - a nasty case of the runs.
     
  18. pinokio

    pinokio Newbie

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    Re: REASEC (Diphenoxylate) recreational potential

    Ah damn, SWIM made mistake again wtf, sorry.

    It contains 0.025mg of Atropine ofc. = 0.475mg per 19 tablets.

    pinokio added 0 Minutes and 12 Seconds later...

    btw why cant i Edit my posts?
     
    Last edited: Jun 3, 2008
  19. Panthers007

    Panthers007

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    Re: REASEC (Diphenoxylate) recreational potential

    You are a newbie-member. Newbies can't edit. As soon as you make silver, the edit button will magically appear. Keep on going. Soon you will impress someone and you will get enough positive reputation points to transmogrify to silver. Fear not.

    Until then you need to call for a moderator to give you an assist with editing.
     
  20. RoboCodeine7610

    RoboCodeine7610 Silver Member

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    Re: REASEC (Diphenoxylate) recreational potential

    Apparently there already is a thread about this: http://www.drugs-forum.com/forum/showthread.php?t=21280 SWIM has access to scientific filters which he uses to extract codeine... Maybe he could try to do a CWE with Diphenoxylate and collect the powder the remains in the filter. Another use would be taking the pills normally and keeping the dosage of atropine low, and combining it with codeine and they should potentiate each other.