TEK - DOC administration methods?

Discussion in 'Phenethylamines' started by dogcow, Nov 14, 2005.

  1. dogcow

    dogcow Silver Member

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    Since there has been some talk of DOC here...

    I am aquiring some DOC for lab testing purposes. What is the method most are using to administer it to test animals? SWIM's first thought was disolving in alcohol, however that is not really convenient for adminstration to test animals "in the field" (outside of my lab) or for administation to SWIM's friends test animals.

    I have heard on this board DON being laid to blotter, however can blotter really absorb 2mg / square? which seems like a reasonable effective dose for DOC

    SWIM figured 100 doses (100 drops) is ~ 1ml of solution, therefore 100mg would be disolved in .5ml isopropyl alcohol to achieve 200mg/ml then laid out dropwise for 2mg/drop dose.

    Is there any way to put it in caps without a scale accurate to UNDER 1mg (My +/- 2mg scale is no good for that).

    I would not be ..... or .... as anything except DOC and just for scientists to use in their lab experiments. I am not a scumbag.

    all comments/help appriciated

    regards

    -dcEdited by: nanobrain
     
    Last edited by a moderator: Sep 11, 2010
  2. Mezza

    Mezza Gold Member

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    You could rack up some gelcaps and add the DOC dissolved in alcohol to the caps, using an oral syringe for accurate dosing. After it evaporates, cap them and you should be good to go. Be sure to test to make sure the alcohol doesnt dissolve the gelcap though...


    You could also try adding your DOC dissolved in ethanol to a sugarcube, altoids, etc. Wrap them individually and store them in the freezer.


    Mezza
     
  3. Toltec

    Toltec Gold Member

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    Use 2-1/2 ml Everclear, vodka or101 etc... < (that will dissolve doc into solution well)\ put it into a shot glass; mix 200mg into the glass too. Mix till it is completely gone.

    Use a syringe that shows/reads 1ml increments to Squirt the solution, squirt the solution very "SLOWLY" onto a 2-1/2 inch by 2-1/2 inch pre cut blotter paper (#14 watercolor paper is best) laying flat on a glass pie plate.That should get you 2mg per 1/4 square.

    When you slowly squirt the solution onto the paper, slowly spread it around too, It absorbs! Don't use a fan to dry it. Let it dry on its own. The blotter paper will pretty much evenly absorb the DOC on its own. If you use to much liquid; say 4ml it will spill off of the sheet.

    That should work;I would practice first to see how it works!If I was to ever try that that’s how id do it. #14 gauge watercolor papers is sold at any art supply store. #14 watercolor papers are what are used to lay LSD with.

    In fact that’s how it’s done except that they use a ten pack of blotters and dunk that into solution to absorb the LSD. What ever is left over under the sheets is scraped up and placed into liquid vials for personal use; and hopefully that is all it is gonna be used for! Please don’t pass this off as LSD!!!!!!!!!!!

    If it is done right for doc there, won’t be any spillover, by the way. Like Nanobrain is gonna say below ~VVVV~ no one knows yet how good/long DOC will stay stable on blotter.

    Edited by: Toltec
     
    Last edited by a moderator: Sep 11, 2010
  4. nanobrain

    nanobrain Platinum Member

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    IMNSHO, layng sheets is a fine art that is taught and nothing to fuck around with unless you know precisely what you are doing.

    pie plates? syringe squirting? unless you have a calibrated injection syringe / dropper you are going to end up with very inconsistent dosing. do you even know the type of paper to use? are you certain your solvent mix will do the trick?

    here's an idea - weigh a lesser amt than 100mg, yet greater than 1-2mg - say 10mg. that's 5 doses rady to be done with as you wish - dissolved, etc. put the rest away in a safe place until further notice. repeat when necessary.

    less chance of error - and if DOC degrades from exposure, well, the more surface area the more exposure, so...
     
  5. dogcow

    dogcow Silver Member

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    thanks toltec!!! :)

    nano : yes I have access to a calibrated micropipete

    -dc
     
    Last edited by a moderator: Sep 11, 2010
  6. Nagognog2

    Nagognog2 Iridium Member

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    As I wrote before on a different subject, someone I know had some DOI sitting around in poor storage conditions for 15 years. It was just fine. An educated guess would be that DOC would survive lengthy storage - especially careful storage, quite well also.
     
  7. oldman

    oldman Gold Member

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    is the alcohol needed instead of water because you want to save it for a while or is DOC not soluable in H2O?
     
  8. Nagognog2

    Nagognog2 Iridium Member

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    DOI.HCl is certainly soluble in water - distilled.
     
  9. oldman

    oldman Gold Member

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    Yeah but is everyone asking about alcohol for some reason oher than water? Preservation. I guess water can go bad over time versus alcohol doesn't.>
     
  10. snapper

    snapper Gold Member

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    water does not "go bad" any more than alcohol does. It is a very stable
    molecule in a normal environment. The only reason to pick one versus the
    other is sulubility. Both predispose unstable chemicals to degrading more
    quickly by exposing them to more light and temperature changes.

    Snapper
     
  11. emineo

    emineo Newbie

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    Apparently a good rule of thumb for liquids with a viscosity similar
    to water is 20 drops per milliliter for a standard medicine dropper.

    This would means 100 drops (approx. 5ml) to achieve 1mg per drop.

    100mg/100 drops = 1mg/1 drop

    Diameter of the hole, temperature, viscosity of liquid, humidity, etc.,
    are all supposed to be factors of ml per drop so nothing is going to
    be as accurate as a set of well calibrated scales.

    As a side note, if you can find an old zero centered galvanometer
    and you know how to read a simple circuit diagram (nothing more
    than capacitors, resistors, batteries, and a potentiometer), there is
    an article in some infamous chemistry archives on how to build a
    homemade milligram (some say microgram if your circuit,
    galvonometer, and voltmeter are good enough) scale.

    Calibrate with a good weight set and you will be AMAZED at the
    accuracy and extremely proud of the accomplishment.

    It looks a little daunting, but very possible. I promise.

    If you're interested in attempting this you should be aware of exactly
    what you'll need for the project to be as "affordable" as the article
    claims. For instance, it assumes you already have a voltmeter. A
    good one that can measure into the low millivolts may run you into
    the $100 range.

    However, if you already have a good voltmeter the rest of the project
    is probably only going to cost you 30 bucks.

    Can someone confirm the info above about drops per milliliter just
    to be certain?
     
  12. allyourbase

    allyourbase Palladium Member

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    250 mg solutes quite readily in 2.4 ml 95% EtOH, giving roughly 2 mg per drop from a standard eyedropper or sweetbreath bottle.
     
  13. Toltec

    Toltec Gold Member

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    Wouldn't it be safer to just use 125mg in2.4 ml ethanol, wich would give you roughly 1-1/4 mg per drop or 50 doses per sweetbreath bottle>


    A 4mg dose of Doc is fairly strong dose for some ppl. Wouldn't you think!Edited by: Toltec
     
  14. allyourbase

    allyourbase Palladium Member

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    its actually more about 2.5 mg


    2.4 ml of EtOH solution is ~ 100 dropsEdited by: allyourbase
     
  15. snapper

    snapper Gold Member

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    Why not use a pipette or micropipette to measure doses. No ambiguity
    over volumes, and drop amount on appropriate carrier of choice.

    Anyone ever try making window panes out of gelatin, BTW ?
    Get some jello and dose out the DOC or whatever in your liquid, drop
    premeasured volumes into individual wells, refrigerate until jello, then let
    dry. Consistency of plastic, but it works and if tinted (ie - grape or
    equivalent opaque color) it will be protected from light..
    I have not done this in a very long time, but recalls it working well.

    SNAPPER