I'm currently on 125 mcg/hour Watson patches (1-100 and 1-25) and I have noticed that now I have a much higher tolerance to other opiates/opioids. Prior to the patch, I could take 30-45 mg. oxycodone, get fair pain relief, and still feel warm and fuzzy. Now, oxycodone, MSIR, and MSER have absolutely no effect whatsoever! I went to hydromorphon (first 2, then 4, now 8 mg.) and oxymorphon (opana ER 40 mg.), and still feel nothing. Today I took 3-8 mg hydromorphon and about 2 hours later chewed 2 opana 40's. Nothing! Is fentanyl so much stronger that tolerance to other opiates should be this high? All of my meds are legit prescriptions for chronic pain and I rarely take them other than as directed, but occasionally I look for that "wrapped in a cloud" feeling. I am somewhat worried that I might find that "just enough" will turn out to be "too much" with a tolerance like this!