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Effects - Does Nicotine affect the effect of other drugs?

Discussion in 'Tobacco' started by dimichaeltryptamine, Jan 22, 2009.

  1. dimichaeltryptamine

    dimichaeltryptamine Newbie

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    Swim uses Nicotine daily, but as soon as THC enters his system Nicotine becomes much more noticeable when consumed. So does Nicotine affect the mind differently when you're under the influence of other substances?
     
  2. poppypreacher

    poppypreacher Silver Member

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    AW: Does Nicotine affect the effect of other drugs?

    Swim experienced that tobacco kicks much more when he is on opiates and loves smoking when on it, but when stoned, he doesn't like the effect of tobacco much and while tripping on magic mushrooms he didn't noticed any effect of nicotine. So obviously some drugs affect the brain chemistry in a way, that nicotine doesn't work similar to the sober brain.

    Here's an article, which may be interesting, though its about the effect of tobacco to cannabis and not reverse


    Adulteration of cannabis with tobacco, calamus, and other cholinergic compounds
    John M. McPartland
    Cannabinoids 2008;3(4):16-20

    http://www.drugs-forum.com/forum/local_links.php?action=jump&catid=98&id=6440
     
    Last edited: Jan 22, 2009
  3. dimichaeltryptamine

    dimichaeltryptamine Newbie

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    Swim thanks Swiy. Very helpful. Swim started out a while back smoking a cigarette after each time he would use cannabis only because he was twelve and didn't want the school to know of his habits, then one day he just noticed the effect. I'm sure it's stronger or lighter effect depending on who uses it.
     
  4. Systemdoll

    Systemdoll Newbie

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    For swim's experience, Nicotine (medical or Snus) potentialise a lot the effects of Oxycodone.

    Cool.
     
  5. Jatelka

    Jatelka Psychedelic Shepherdess Platinum Member & Advisor

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    Most Definitely! There's a great paper here

    that looks at the effect of nicotine on various pharmaceuticals, including Tricyclics, SSR's, Benzodiazepines and Typical/Atypical antipsychotics
     
    Last edited: Jul 9, 2009
  6. chillinwill

    chillinwill

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    Red Rock loved to smoke when on DXM, opiates, and of course while drinking. He found that nicotine potentates the effect of DXM and smoking is very, very enjoyable while drinking alcohol. On opiates, he doesn't have a care in the world and could chain smoke then as well
     
  7. doublezero

    doublezero Silver Member

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    swim says yes, but u wouldnt notice it,,,unless u wernt an addictive smoker,
     
  8. Systemdoll

    Systemdoll Newbie

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    Thank you Jatelka for your link. Do you have any infos on effects and potentialisation of opioid and nicotine ?
     
  9. Systemdoll

    Systemdoll Newbie

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    A friend of mine write a little text about interaction between oxycodone and nicotine:

    [​IMG]

    An illustration of the metabolic pathways of oxycodone with the associated
    CYP-enzymes after oxidative (white arrows) and reductive (black arrows) reactions.
    The percent values are given for normal conditions (without nicotine).

    The values represent percentages of plasma consentrations (Cmax values, ng/ml) after a
    single 15 mg oral dose of oxycodone in humans. Modified from Lalovic et al. (2006).
    Oxycodone has relatively high oral bioavailability in humans (60-87%) (Leow et al.
    1992; Pöyhia et al. 1992b) compared with that of morphine (19-30%).
    Oxycodone is extensively metabolized in the liver and only 8 to 14 % is excreted
    in unchanged or conjugated forms to urine (Pöyhia et al. 1992b). According to Lalovic
    et al., oxycodone undergoes minimal oxidation in the intestinal mucosa during the firstpass
    oxidative metabolism compared with the liver (Lalovic et al. 2004).

    In humans, the main oxidative metabolic route of oxycodone is N-demethylation
    at the 17-position by CYP 3A4/5 (CYP) 3A4/5 to noroxycodone (Pöyhia et al. 1991;
    Pöyhia et al. 1992b; Kaiko et al. 1996; Heiskanen et al. 1998; Lalovic et al. 2004;
    Lalovic et al. 2006).
    Noroxycodone is further metabolised to the reduced forms α- and
    β-noroxycodol (Fig. 1). A reductive metabolism of oxycodone occurs with a lower rate
    to α- and β-oxycodol (Fig. 1).

    Oxymorphone is a 3-O-demethylation metabolite of
    oxycodone and it is formed after oxidative reaction mainly catalysed by CYP 2D6 in
    humans (Otton et al. 1993). Oxymorphone is extensively conjugated and excreted in
    urine mainly as in the conjugated form (Cone et al. 1983; Pöyhia et al. 1992b; Kirvelä et
    al. 1996; Lalovic et al. 2006). The reductive metabolites of oxymorphone are α- and β-
    oxymorphol (Fig1).
    Noroxymorphone is formed mainly after O-demethylation of
    noroxycodone by CYP 2D6. Also, a minor route is by N-demethylation of
    oxymorphone to noroxymorphone via CYP 3A4 and 2D6 approximately with a 20- to
    30-fold lower rate compared with noroxycodone O-demethylation (Lalovic et al. 2004).
     
  10. Enzo_Guy

    Enzo_Guy Silver Member

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    SWIM has found both alcohol and cannabis boost the effects of smoking a cigarette. Cannabis also gives his favorite cigars a better flavor.
     
  11. lulz

    lulz Gold Member

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    Smoking a cigarette generally dulls a drug experience for swim. If stoned, a cigarette makes him feel less stoned. If drunk, less drunk. It dampens euphoria as well. Swim thinks his brain behaves uncommonly in this respect though.
     
  12. ziek

    ziek Newbie

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    Drinking and Smoking is lovely. Both seem to taste so nice and a beer and a cigarette feel like the perfect match!
     
  13. nibble

    nibble Titanium Member

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    Nicotine increases the subjective euphoria of many drugs through it's well-known property of increasing dopamine tranmission in the reward pathway. Well known examples would be cocaine users often chain smoking when using as it augments and intensifies the high, the same goes for just about any drug that increases dopamine in the reward pathway to an appreciable extent.