1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

Effects - DXM not working anymore

Discussion in 'DXM' started by faren1, Oct 2, 2007.

Thread Status:
Not open for further replies.
  1. faren1

    faren1 Silver Member

    Reputation Points:
    1
    Messages:
    71
    Joined:
    Jul 23, 2007
    33 y/o from New York, U.S.A.
    I have tried DXM about 3 or 4 times with amazing results about 2 of them. I am wondering why at the same dosage, about 360mg, sometimes I have a great experience and othertimes barely feels anything.
     
  2. Graduisic

    Graduisic Palladium Member

    Reputation Points:
    734
    Messages:
    467
    Joined:
    Jun 20, 2007
    29 y/o from U.S.A.
    tolerance may be an issue. in the future, You should be more specific about dosages, such as, the amount of time spent between doses
     
  3. Paracelsus

    Paracelsus Platinum Member & Advisor

    Reputation Points:
    2,845
    Messages:
    2,497
    Joined:
    Aug 31, 2006
    from U.S.A.
    Another important factor (if chronic use is not the case) is stomach contents. If taken on an empty stomach (4-5 hours after last meal), DXM is much more potent.

    From my vampire's one-year-old stories I know that the same dose that would be very potent on an empty stomach can have a delayed, weak and extended effect when consumed after a meal.
     
  4. lsh

    lsh Newbie

    Reputation Points:
    5
    Messages:
    13
    Joined:
    Aug 6, 2007
    40 y/o
    What is a safe dosage of DXM? I've got that cough medicine that contains only DXM but I don't know how much to take.

    Thank you!!
     
  5. Paracelsus

    Paracelsus Platinum Member & Advisor

    Reputation Points:
    2,845
    Messages:
    2,497
    Joined:
    Aug 31, 2006
    from U.S.A.
    The safe dosage is up to 30 mg. Recreational doses start at 1.5 mg/kg (105 mg for a 70kg person), which would most likely be safe for a first-time user. But that first time user certainly isn't YOU.
     
  6. darkglobe

    darkglobe Silver Member

    Reputation Points:
    316
    Messages:
    765
    Joined:
    Dec 12, 2006
    from U.K.
    SWIM's first use was (don't laugh!) 80mg of DXM.

    Taken on an empty stomach, In syrup form.

    It produced a somewhat strange "floaty" feeling, and made speaking slightly awkward. Also gave SWIM the "jumpy" feeling that around 50+mg of Diphenhydramine gives.

    Not unpleasant, apparently. I'm told it was actually very enjoyable.

    Subsequent use (literally the next use and all others) required sharply increasing dosaging in order to achieve the same effects.

    SWIM (long-term user, but not regular at all) says that is personal dosages are as follows:
    1st plateau - almost unattainable these days. Either gets negligible effect or ends up with double vision.
    2nd plateau - around 400mg
    3rd plateau - 800mg
    4th plateau - I have never knowingly reached this plateau, neither has he ever taken more than 800mg.

    Incidentally, I weigh 76.7Kg and is male, in good health and aged 19 years.
     
  7. lsh

    lsh Newbie

    Reputation Points:
    5
    Messages:
    13
    Joined:
    Aug 6, 2007
    40 y/o
    Thanks for the advice. And SWIM never took it in the end, in case it reacted with the SSRI's he's taking (escitalopram.) He decided to read up on the subject as it was completely new to him, he'd never even heard about it from friends etc...

    It seemed to me though that the information regarding SSRI's and DXM interaction is confusing - I'd read 1 thread and think "no way I'd try it", and then another thread seems to describe the combination as beneficial and better.

    Anyway, I'm going to read some more on the subject as it's interesting to me.
     
  8. darkglobe

    darkglobe Silver Member

    Reputation Points:
    316
    Messages:
    765
    Joined:
    Dec 12, 2006
    from U.K.
    Read away :)

    Just make sure You doesn't take anything that could react nastily with those SSRI's.
     
  9. FooDawg

    FooDawg Newbie

    Reputation Points:
    2
    Messages:
    16
    Joined:
    Oct 1, 2007
    34 y/o
    Isn't DXM an NMDA antagonist? Does it even touch serotonin? I haven't seen anything about DXM and SSRI interactions in the past, but then again he has never looked for it. Good to see that You is being cautious and safe though. Anyone know anyone more knowledgeable on the exact effects DXM has on the brain? Maybe an extraction would be best for someone on SSRI's since I am almost positive (just don't quote him, lol) DXM is just a straight NMDA antagonist. Maybe there is more to it?
     
  10. FooDawg

    FooDawg Newbie

    Reputation Points:
    2
    Messages:
    16
    Joined:
    Oct 1, 2007
    34 y/o
    I am retarded, he did a little bit of quick research and guess DXM does block serotonin uptake. So definitely good thing You did some research and be careful above all else. You might still be able to experiment, but if You does, make sure the remain as cautious as they have been. I am sorry for the misinformation, wishes he could edit his posts.
     
  11. FooDawg

    FooDawg Newbie

    Reputation Points:
    2
    Messages:
    16
    Joined:
    Oct 1, 2007
    34 y/o
    http://www.uspharmacist.com/oldformat.asp?url=newlook/files/feat/acf2fa6.htm
    -and-

    Dextromethorphan should not be taken with any of the following:
    "DXM taken with any of these can cause Serotonin syndrome, a potentially life-threatening adverse drug reaction that results from intentional self-poisoning, therapeutic drug use, or inadvertent interactions between drugs which cause an excess of serotonergic activity at central nervous system (CNS) and peripheral serotonin receptors."

    -Wikipedia page-
     
  12. darkglobe

    darkglobe Silver Member

    Reputation Points:
    316
    Messages:
    765
    Joined:
    Dec 12, 2006
    from U.K.
    I'm not au fait with Pharmacology.... but....

    http://www.erowid.org/chemicals/dxm/faq/dxm_neuropharm.shtml#toc.10

    Should give ya what ya need to figure it out yourself.

    As far as I'm aware, Serotonin Syndrome can occur with chronic DXM abuse. I think.

    EDIT: I will be able to edit posts soon, just continue to post well and you'll become a silver member :)
     
  13. Paracelsus

    Paracelsus Platinum Member & Advisor

    Reputation Points:
    2,845
    Messages:
    2,497
    Joined:
    Aug 31, 2006
    from U.S.A.
    Actually, DXM is a very low affinity NMDA antagonist. DXM acts mainly Sigma and PCP2 receptors. DXM is also a serotonin reuptake inhibitor and a serotonin receptor agonist.

    There are some reports on this forum about certain SSRIs interacting nicely with DXM, but there are also reports of serotonin syndrome followed by this combination. The key is keeping track of the doses. If SWIlsh decides to try DXM, the doses should be much lower and raised carefully. Starting at around 80-100 mg and raising the dose in steps of aroun 50 mg would be fairly safe in that situation. Keep in mind that escitalopram also potentiates DXM by inhibiting CYP2D6.
     
  14. FooDawg

    FooDawg Newbie

    Reputation Points:
    2
    Messages:
    16
    Joined:
    Oct 1, 2007
    34 y/o
    I was going on the thought that it reacted quite a bit with the NMDA receptors. Here is why:

    http://www.erowid.org/chemicals/dxm/faq/dxm_physiological.shtml#toc.9.2.4

    I would like to take the time to go through the articles he/she cited at some point once SWIM's own research writing slows down a bit.
     
  15. Paracelsus

    Paracelsus Platinum Member & Advisor

    Reputation Points:
    2,845
    Messages:
    2,497
    Joined:
    Aug 31, 2006
    from U.S.A.
    I forgot to mention that in the post above. DXM is a very weak NMDA antagonist, but dextrorphan is a much more potent one. Dextrorphan is also believed to be responsible for the pleasant effects of DXM. You can find a thread called 'Psychotropic effects of dextromethorphan are affected by CYP2D6 polymorphism: a pilot study' or similar in the DXM forum.

    Since this thread has changed topics twice, it is now closed. Discussion can go on in more suited threads.
     
Thread Status:
Not open for further replies.