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Drug info - Ecstasy - make 1 pill more effective?

Discussion in 'Ecstasy & MDMA' started by gstq, Nov 22, 2006.

  1. gstq

    gstq Newbie

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    If there is someone who is 6'3" @ 265 lbs and 1 average ecstasy pill has no effect on them, but 2 ecstasy pills is perfect, is it possible to somehow make 1 pill work? Is there any way to cocentrate the MDMA in that pill to make it more effective? For example, apparently:

    Orange Juice + 1 pill = equiv. to 2 pills

    Is this true? If not, any other suggestions? Assume the person using the pills is relatively new to ecstasy and has only popped about 6 pills in their lifetime. Assume that their tolerance is still relatively low, but their natural tolerance to substances (ie. body height/weight) is high. 1 pill does nothing, 2 does a fantastic job.

    Is there any way to make 1 pill have the same affect?

    Thank you.
     
  2. Andrewilson

    Andrewilson Newbie

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    There are a few meathods swim could try to make one pill more effective. One would be to fast for the day leading up to injesting the pill. Another is pre-loading, takeing either 5-htp, or tryptophan befor the pill is taken. You could also try other meathods of injestion, chewing the pill or grinding it up and parashuteing it helps it to kick in faster. Or insuphalteing the pill, in which more of it is abosrbed through the mucous lineing of the nose then would be absorbed through the stomache lineing. My best advice would be the preloading + fasting + chewing the pill.


    plur
     
  3. sterling77

    sterling77 Iridium Member

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    Plugging is the best answer anyone here will give you. If swim doesn't want to try that he'd recommend fasting + tums 20 minutes beforehand. What swim wouldn't recommend is orange juice, which decreases the absorption of amphetamines.
     
  4. TitusCrow

    TitusCrow Newbie

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    SWIM found that snorting the XTC pills were the most effective way of getting the full potential of each pill. Although, SWIM had never used the " Plugging " method ".

    SWIM would take antioxidant multivitamins on a regular basis.

    SWIM read somewhere that antioxidants have been proven to reduce neurotoxicity and also somewhat decrease the tolerance build up of MDMA.

    SWIY should give it a try.
     
  5. GForce

    GForce Gold Member

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    Two things SWIM usually likes to have when he is taking E; 5-HTP and Vitamin C pills. The orange juice statement definitely has some validity. SWIM wouldn't go as far as to say that it would double the effectiveness of a pill, but Vitamin C definitely helps with effectiveness. SWIM is pretty sure Vitamin C intensifies the acid in your stomach causing your body to absorb MDMA faster. However, SWIM has also heard that the acidity can also neutralize some of the amphetamine. From what SWIM has put together it seems to be a little bit of both; the acidity may very well neutralize some of the amphetamine but in turn makes the roll less speedy and more serotonergic. For what its worth, he always takes Vitamin C with E. As for 5-HTP (otherwise known as tryptophan), it is an essential building block of serotonin. SWIM usually doesn't use it before a roll, but rather after. He finds that it helps dampen the comedown by boosting serotonin levels post-roll. Although, and very surprisingly, he has re-started a roll for an hour or two by smoking cannabis and taking 5-HTP. Hope this helps.
     
  6. Alfa

    Alfa Productive Insomniac Staff Member

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    How about potentiating by increasing uptake?
    Cafeine increases uptake of substances in the bowels.
    Ginkgo increases blood flow in the brains, and therefore increases effects of many drugs. There are several drugs which do the same. Piracetam may be an option as well, but that needs imput of others.
    Vitamines definately play an important role in mono amine metabolism. Which vitamine(s) to add depends upon what your test rat wants to enhance: Dopamine(B6), serotonine(B6), adrenaline(B3).
    Dissolving tablets may be an option when the test subject wants to trade in a slow onset for a heavy hit.
     
  7. betsym

    betsym Newbie

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    Has anyone heard that anti-rejection drugs used for organ transplant patients reduces all tolerance to e? I am not sure how that would work or that it would be safe, as anti-rejection meds drastically lowers immunity. Research hasn't turned up much on this but SWIM did hear something about it during the course of research. SWIM has used, and contiues to use Piracetam and Oxiracetam for the effects on the brain and has used it for increasing the effect of e and found it to work very well. Plugging the pill and using Piracetam works even better. If there is much tolerance to e, as needing 2-3 pills for good effect, even a tiny person weighing less than 100 pounds, would find it hard for 1 pill to have as good an effect as desired. SWIM takes tums, drinks grapefruit juice, and takes the supplements mentioned. L-deprynl has come to attention as a life-expanding supplement that can also be beneficial for lowering tolerance. Swim's friends are in the process of finding out about that and will get back to Swim about it.
     
  8. GForce

    GForce Gold Member

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    What is plugging the pill? I think I figured it out since it seems to refer to the type of ingestion, but I mean if its what I think it is... c'mon, that seems a bit overboard to have a good time on E.
     
  9. Alfa

    Alfa Productive Insomniac Staff Member

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    That gives a whole new meaning to going to the bathroom to do drugs. ;) Don't forget to wash hands. lol.
     
  10. GForce

    GForce Gold Member

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    Yeah, guess I did figure it out haha.
     
  11. geezaman

    geezaman Gold Member

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    Body weight may be a factor we often use to suggest a suitable dose, bigger people taking bigger doses than smaller people but SWIM does not believe this to be necessarily true. On pills bought as MDMA, that SWIM 13stone and a friend 11 stone considered to be weak a third friend 16 stone had a full, and his best to date experience on.

    Is there some factor of what the stomach is doing?
    SWIM is aware that with some drugs (sadly cannot remember if an effect on E), It seemed as though having a snack after-wards had a direct effect on the speed the drugs kicked in. Presumably after eating the chemical mix in the stomach changed, or the digestive process is started, increased in speed, something along those lines. Has any other SWIYs experienced this? Or can any SWIYs confirm or dismiss it?
     
  12. darawk

    darawk Gold Member

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    The most efficient absorption method is obviously an I.V. Yes, you can inject MDMA. However, you'd better be damn sure it's MDMA you've got in those pills before you go that route.

    You have a couple different places where you can "attack" this problem.

    1. Absorption: You can potentiate this using caffeine and ant-acids, as has already been suggested. However, a very potent substance for this purpose that hasn't been mentioned yet is bioperine. It will increase the absorption of just about anything its taken with.

    2. "Readiness" of your brain and its neurotransmitters: Preload with 5-htp/tryptophan/l-dopa. Why l-dopa(mucuna pruriens extract)? Because dopamine is fun too. The 5-htp/tryptophan thing is somewhat controversial though. Many people swear it intensifies their roll, but many others say it weakens it. So, experiment for SWIY's self with that one.

    3. Post-ingestion: There are a lot of other drugs out there that will increase the efficacy of MDMA. Alkyl nitrates(poppers) will cause a massive rush of blood to the head, that can kick start your roll, same with nitrous oxide. Nicotine and marijuana also tend to potentiate the effects of E. Even hyper-ventilation can help, taking long deep breaths somewhat quickly. SWIM's first time rolling he wasn't feeling it at all until his friend suggested he stop dancing for a bit, take some deep long breaths and just relax. Then it hit SWIM real hard.
     
  13. FrankenChrist

    FrankenChrist Iridium Member

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    One dose probably won't hurt, but when I was on them for allergic symptoms I had to get my blood checked every month. That's all I know about anti-rejection drugs. Also they taste like Satan.

    Oh and I don't know about the poppers combo. You may get a bit of spins and a fight with gravity for a short while, plus the feeling in your head and your heart might not always be nice.
     
  14. betsym

    betsym Newbie

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    Swim's friend has experience with iving MDMA but using the pure powder, not pills. If the pill does not dissolve completely in water, then it is best not to inject it, because it it not pure MDMA. However, there are pills which are pure MDMA. Iving does provide a more intense experience but is not the usual method that most people would want to use since it is more complicated than simply swallowing a pill and swiy has to know what they are doing or know someone who does.
     
  15. Fantasian

    Fantasian Newbie

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    Could SWIY write about his friends IV experience of MDMA, SWIF is very interested in this and any experience would be greatly appriciated. PM me if you would prefer to keep it private.
     
  16. Vysas

    Vysas Newbie

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    SWIY can try to take a quater of pill on every 20 min.Second option is sniffing.
     
  17. Bajeda

    Bajeda Platinum Member & Advisor

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    How would either of those methods produce a stronger roll?!? :confused:
     
  18. Vysas

    Vysas Newbie

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    SWIM taked 8 quater(2 pills) on every 20min.Effect is much stronger.Sniffing of xtc is strongly not recomended,but xtc start to work immediately.
     
  19. geezaman

    geezaman Gold Member

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    SWIM agrees that snorting/sniffing a crushed pill will bring on some effects more quickly as entering via the nasal tissue, but this was not worth it for SWIM just really dam painful. As for the 1/4 every 20mins SWIM is stumped too. SWIM has been told learned from hear and experienced, that if the warm lovey effects are wearing off to re-dose 1/3rd the original dose. (More will just bring the amphetamine like effects forward), but that would'nt help the thread starters problem particularly, would it?
     
  20. inferno420

    inferno420 Mercury Member

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    my dog id about your weight and height and he doesnt eat 6 hours prior to taking the pill, so that usually does the trick.