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Drug info - Etaqualone

Discussion in 'Research Chemicals' started by 0utrider, Nov 16, 2008.

  1. 0utrider

    0utrider Palladium Member

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    hi
    any information about this? couldnt find anyhting on erowid..
     
  2. Mish

    Mish Silver Member

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    SWIM has recently managed to get ahold of 1g of Etaqualone and was interested in finding out some general (and more detailed chemical and biological) information about it. SWIM was hoping that by way of some of the SWIY-chemists residing on this forum, deductions could be made from the structural similarities between this compound and it's "popularized" cousin, Methaqualone (Quaaludes/Mandrax)...

    Methymethaqualone (MMQ) did nothing for SWIM orally at 250mg - and SWIM didn't want to go above that for fear of the low seizure threshold - and, when 20mg was smoke, produced a short but distinctively dissociated rush of mild euphoria. SWIM's overall impression was not great.

    However, SWIM has just come across this analogue Etaqualone. This, it seems, is much more likely to have an effect as it is structurally a lot similar to the original Quaaludes. Below is a comparison of chemical formulas for the analogues that seem to be available:

    • Methaqualone: 2-methyl-3-(2-methylphenyl)-4-(3H)-quinazolinone
    • Etaqualone: 2-methyl-3-(2-ethylphenyl)-4-(3H)-quinazolinone

      as opposed to

    • Methylmethaqualone: 2-methyl-3-o-tolyl-4(3H)-quinazolinone

    SWIM is not particularly familiar with the chemistry of these structures, but is aware that the addition of the prefix 'Methyl-' in the MMQ analogue meant for supposedly faster absorbtion/onset; and that the 'o-tolyl-' addition also has the drawback of lowering the seizure threshold.

    However, it seems that Methaqualone and Etaqualone are almost identical in structure, so it should thus follow that they should have near identical effects...? What differences occur to effects/bioavailablity when the -methyl group is substituted by an -ethyl group? (as in: '2-methylphenyl' for Quaaludes, and '2-ethylphenyl' for Etaqualone?

    From SWIM's (admittedly very, very limited understanding), this would just mean a shorter duration of effects. Is this correct?

    From 2 separate sources, SWIM has heard that:

    This seems to be somewhat contradictory to SWIM. If the ethyl group shields neighbouring groups then subsequently Etaqualone should become less bioavailable than Methaqualone. If someone could relay the above information into laymans' term SWIM would be much appreciative.

    There are little to no reports out on the 'net regarding Etaqualone experiences; presumably because it has only been fairly recently synthesized or - more likely - brought into the public eye.

    SWIM is interested in the pharmacokinetics of this compound as he knows how popular Rorer 714's (300mg Methqualone in a capsule) were because in the 1960's and 70's, and was wondering how such a seemingly minor change can really alter the drugs effects...

    However, being in possession of a small amount of Etaqualone means that SWIM is also most interested in the dose. SWIM has heard from other sights and reports that a dose of about 250mg orally produces a hypnotic sedating euphoria that lies somewhere between Diazepam and GHB - would this be true?

    SWIM is considering both oral ingestion [250-300mg], inhalation [100mg], and insufflation [200mg] but would like to know which is the best. Bearing in mind SWIM has a naturally high tolerance to most GABA A receptor agonists (14mg of Clonazepam to feel anything; 60mg Diazepam; 160mg Temazepam; 80mg Zolpidem/Ambien) and, to a lesser extent GABA B agonists, where would a good starting dose be orally?

    If anyone has had any experience with 'ludes in any form then please post them, as DF seems to be lacking in subjective experience reports that actually go into details about the dosages and explicit effects.

    Thanks :)

    EDIT - Even though this is a thread is really looking for guidance and general 'Drug Info' on the compound, SWIM is aware that it may have been placed in the incorrect sub-forum of the board. If so, please feel free to move it.
     
    Last edited: Nov 23, 2008
  3. Synesthesiac

    Synesthesiac R.I.P.

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    Re: Methaqualone (Quaaludes)

    Dont know if this should be here or in the research chems section. There appears to not be any decent report of Etaqualoneusage dosage and effects anywhere on the internet, but a popular online vendor has just got a lot of this in stock, so no doubt there will be a good few reviews about soon.

    From the very few reports I've read, some say Etaqualone is very similar to its illegal analogue Methaqualone but has a much shorter duration, and some people claim no effects at all. But they may have got it from a dodgy vendor selling flour. You never know. And apparently it may not be very water soluble, so it may not be as effective nasally as orally, but this is based on only hearsay at this point.

    Keep us posted if swiy does it. And with something this new and unknown its always a good idea to start very small. Even at 1-5mg to test for allergic reactions.
     
  4. Synesthesiac

    Synesthesiac R.I.P.

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    Cant find anything about this one, and swim has the oppertunity to get it but doesn't want to waste his money on something that no-one seems to have written up about yet. Theres been a couple of reports on various boards over the last day or so, as this one seems to have literally just been rediscovered by some company last month, but no full reports with any of the vital info you would want to get. I doubt its going to be as good as its illegal analogue Methaqualone, but the effects will probably be similar, you'll probably just need more to get the same buzz.

    One I found written literally yesterday:
    Maybe its not active nasally? Or maybe you just need more than that. There seem to be quite a few people saying its not active at all.

    And one more written today:
    And thats all I could find. There will no doubt be a good few more about in the coming weeks though, but swims definately gonna wait until some more detailed reports are out.
     
    Last edited: Nov 25, 2008
  5. Mish

    Mish Silver Member

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    Re: Methaqualone (Quaaludes)

    SWIM tried 200mg nasally last night (after 1mg to test for allergic reactions). No effects whatsoever.

    SWIM will try 500-600mg orally tonight and see what happens. SWIM is aware of rapid tolerance developing so reckons this dosage would normally equate to 300-400mg orally (assuming no tolerance).

    SWIM will report his findings later on; perhaps doing some form of live report as the 'net is severely lacking in subjective experiences...
     
  6. Synesthesiac

    Synesthesiac R.I.P.

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    Re: Methaqualone (Quaaludes)

    Swiys experience seems exactly the same as some other guy I read elsewhere who did 200mg nasally and got nothing. There is another thread about this stuff in the RC section where I posted the only two brief experiences I found for Etaqualone; http://www.drugs-forum.com/forum/showthread.php?t=71586 They are both conflicting, one says nay, and one says yay, but they dont give any detailed information at all really.

    What would be good is a way to test this stuff to see if it really is what people think they've got, but I dont have a clue how that could be done.
     
    Last edited: Nov 25, 2008
  7. 0utrider

    0utrider Palladium Member

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    but i kinda doubt that it isnt active at all.. why would it be available then? the place where its from is usually very very reliable
     
  8. 0utrider

    0utrider Palladium Member

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    Re: Methaqualone (Quaaludes)

    yeah would be nice if SWIY could post his experiences in that post.
     
  9. Herbal Healer 019

    Herbal Healer 019 Silver Member

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    Re: Methaqualone (Quaaludes)

    For what ligitamate reason were quaaludes completely banned from pharmaceutical production? was it simply high instances of abuse?

    In that case, y havent pharma companies completely banned opiates, amphetamines (including meth or desoxyn), & benzos, which all are commonly abused, but like quaaludes have legit medical purposes?

    Did benzos replace ludes?
     
  10. 0utrider

    0utrider Palladium Member

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    Re: Methaqualone (Quaaludes)

    yes they did, as they replaced barbiturates, prolly because the LD50 was a lot higher with benzos. it was quite easy to kill oneself with the others
     
  11. Mish

    Mish Silver Member

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    Re: Methaqualone (Quaaludes)

    Hahah, the negative quote is SWIM under a different name :) Which site was that from? BL? CHL?

    SWIM will be taking 600mg in 30 minutes.
     
  12. 0utrider

    0utrider Palladium Member

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    Re: Methaqualone (Quaaludes)

    please report back, SWIY! :D
     
  13. Mish

    Mish Silver Member

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    Re: Methaqualone (Quaaludes)

    Nothing. SWIM took a total of 800mg on an empty stomach with no effects. Really annoying.
     
  14. 0utrider

    0utrider Palladium Member

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    Re: Methaqualone (Quaaludes)

    what.. that IS strange..
     
  15. rocksmokinmachine

    rocksmokinmachine Gold Member

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    Re: Methaqualone (Quaaludes)

    Very strange indeed, etaqualone is structurally similar (almost indentical infact) to methaqualone.

    It would be interesting if someone who knows a little more about chemistry than SWIMself to comment on this, and perhaps provide an explanation as to why this may have happened.
     
  16. Mish

    Mish Silver Member

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    Re: Methaqualone (Quaaludes)

    SWIM is guessing it is some personal enzyme deficiency, although others have reported almost no effects as well. SWIM is giving up on the Quinazolinone family, as it just doesn't seem to be working for him...

    Shame, as SWIM thought it sounded like the perfect downer tailored for him.
    Still, any SWIY's out there who've tried this stuff - please report. It's always good to have other subjective info... :)
     
  17. rocksmokinmachine

    rocksmokinmachine Gold Member

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    Re: Methaqualone (Quaaludes)

    After time spent in South Africa (Jo'Burg), SWIM came across 'Mandrax' being sold on the street. After unwrapping the package the pills were stamped and colourful (as ecstasy tablets would be), he thought he'd been ripped off.

    After doing a little research he came across something like this site.

    xxxx

    I think this was actually the site, ehh. SWIM's experience (smoked), as seems to be the most common method of injestion over there. Was FANTASTIC. Being a lover of benzo's, and barbs. This was one of the best things SWIM has ever felt. It was like a huge RUUUUUSHHH that floored him, he Can't remember much after that.
     
    Last edited by a moderator: Oct 11, 2009
  18. Synesthesiac

    Synesthesiac R.I.P.

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    Re: Methaqualone (Quaaludes)

    Swim would always be scared of smoking something due to the risk of it creating new unwanted particles that are harmful that wouldn't otherwise be there if swallowed of sniffed. But thats just swim.

    This is interesting, maybe this is like DMT, not active hardly at all when swallowed or sniffed but only when smoked. Wouldn't have a clue why this is the case though.
     
  19. rocksmokinmachine

    rocksmokinmachine Gold Member

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    Re: Methaqualone (Quaaludes)

    DMT needs and MAOI (monamine oxidase inhinbitor), to work orally. Basically MAOI is an enzyme which breaks down serotonin in the brain.
     
    Last edited: Oct 17, 2009
  20. DcJack

    DcJack Newbie

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    Ofcourse REAL Ethaqualon are active, it was sold in many european countries before as a legit medical. So that can't be real Ethaqualone if it isn't active at all.