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Drug info - Ethylphenidate Drug Info

Discussion in 'Research Chemicals' started by davestate, Jul 4, 2010.

  1. davestate

    davestate Gold Member

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    Can anyone add information about Ethylphenidate:

    • names / synonyms
    • molecule
    • dose
    • duration
    • side effects
    • legal status
    • have there been any reported incidents with this compound?
    • since when has this Research Chemical been available?
    • stability of the molecule / compound


    [​IMG]



    IUPAC name: ethyl 2-phenyl-2-piperidin-2-ylacetate
    CAS number: 57413-43-1
    Mol. mass: 247.33274 g/mol
    Pubchem ID CID 3080846
    MP: 175-179˚C
    Some related (experience) threads:
    Alcohol + Methylphenidate = Ethylphenidate
    Ethylphenidate - Very Satisfying High
    methylphenidate -> ethylphenidate
    All of the above threads deal with co-ingestion of ethanol and methylphenidate, not the ingestion of the pure compound.

    Ethylphenidate is the ethyl ester of 2-phenyl-2-(2-piperidyl)acetic acid, in the similar manner that methylphenidate is the methyl ester

    Ethylphenidate has appeared at some UK based research chemical suppliers, touted as a replacement for cocaine. Ethylphenidate reportedly and according to several studies, has higher affinity for the dopamine transporter, but a lot less activity at the nor-epinephrine receptors, apparently this causes more euphoria, with a lot less jittery/side effects than methylphenidate. It is commonly available as the HCl salt, designed for oral or nasal application and as the freebase, which is touted as a replacement for crack cocaine, as it apparently can smoked/vaporised "crack style"

    Side effects are likely to be the same as methylphenidate, although nervousness, jitters and paranoia may be lessened due to the lesser effects on norepinephrine transporter. Side effects and coping with them can be found in these methylphenidate threads:
    Methylphenidate Comedown (Ritalin, Concerta)
    A way to almost cure the ritalin crash
    as well as that massive information can be found on methylphenidate here. bear in mind effects and doses are similar
    Comprehensive Methylphenidate Information

    Legal status: Not mentioned in the UK's Misuse of drugs act, and no analogue wording covers esters of Ritalinic acid, as well as this it is being sold by UK based research chemical suppliers
    In the US: Since methylphenidate is a schedule 2 substance,and ethylphenidate is merely the ethyl ester instead of the methyl, the federal analogue act definitely applies, no ambiguity there, so it is illegal


    Starting Dose

    For racemic ( (S)-ethylphenidate is more active then the (R)-ethylphenidate )

    Insufflated

    10 - 25mg - Threshold
    20 - 50mg -Average
    40 - 75mg - Strong
    75+mg - Very strong

    Smoking
    (as freebase)
    Users report this is very harsh on the lungs and throat

    IV

    No concrete reports with "safe" doses

    IM
    ?

    Oral

    Doses for oral are between 50-100% more than snorting

    Rectal
    Similar to snorting, but seems to come on faster, slightly lower doses requiredThreshold/study aid: 5-15mg
    Average: 10-30mg
    High: 40-60mg
    Strong: 50-75+mg


    Main effects


    Focus/mental clarity
    Abstract thinking
    Euphoria
    Stimulation
    Increased music appreciation
    Warm fuzzy body high
    Increased sociability/desire to talk[FONT=Calibri, sans-serif]
    Wakefulness

    Promiscuity/increased sex drive


    Side effects

    Tachycardia
    Chest pain
    Vasoconstriction
    Jaw tension/bruxism
    Dick shrinkage/erectile disfunction
    Restlessness
    Inability to concentrate on one task
    High BP
    Panic attacks
    Compulsion to redose
    Insomnia
    Pain (sometimes severe) from snorting, possible nasal damage, nose bleeds
    Paranoia
    Muscle tension
    Anorexia

    Ethylphenidate wiki:
    http://www.drugs-forum.com/forum/showwiki.php?title=Ethylphenidate


    Ethylphenidate experiences:
    http://www.drugs-forum.com/forum/showthread.php?t=156994


    [insights]Ethylphenidate[/insights]
     

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    Last edited by a moderator: Apr 30, 2017
  2. OrbitalSPIN

    OrbitalSPIN Newbie

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    Re: Ethylphenidate

    Thats very interresting. Because SWIM has used both Methylphenidate and Dextroamphetamine before and was surprised when SWIM found out Dextroamphetamine wasn't as euphoric. SWIM has also loved the buzz of the Alcohol and ritalin combo and now SWIM wondering about this... Ethylphenidate.
     
  3. sid91

    sid91 Silver Member

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    Re: Ethylphenidate

    SWIM sampled 100mgs of Ethylphenidate the other day and to be honest felt nothing. No euphoria, no stimulation - nothing! No side effects like dry mouth or gourning - nothing! SWIM may as well have taken a paracetemol. The only thing that SWIM can think of that may have affected this is his trying of Diclofensine the night before but can't see any reason why it would have effected him like this.

    However a friend of SWIMs claimed to also have tried ethylphenidate and reported mediocre euphoria but no stimulation. Please bear in mind this is hearsay and don't go out buying ethylphenidate on this basis.
     
  4. Piglet

    Piglet Titanium Member

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    Re: Ethylphenidate

    Piglets friend Eyore snorted 3 fat lines & I liked it. A lot smoother than pervatin & it only lasted about 2 hours. He thinks this was racemic product, the D enthryo pure isomer is SUPPOSED to be on it's way & that should be 2.4x stronger. Eyore hasn't tried smoking the freebase but apparently 20mg gives a real crack-like rush.
     
    Last edited by a moderator: Sep 10, 2010
  5. gammabetalactone

    gammabetalactone Silver Member

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    Re: Ethylphenidate

    SWIM used 500mg over 8 hours and the only real effects was euphoria, there was no real stimulation. Would make a great anti-depressent. There was a nice afterglow and SWIM felt really good about himself but he would not buy it again.
     
  6. User-126494

    User-126494 Newbie

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    Re: Ethylphenidate

    In addition to some of the fine information presented here, there's a hamster who would like to point out that there is also some good information in these papers in the archive:

    Synthesis and Pharmacology of Ethylphenidate Enantiomers: The Human Transesterification Metabolite of Methylphenidate and Ethanol

    and here:

    Methylphenidate and its ethanol transesterification metabolite ethylphenidate:brain disposition, monoamine transporters and motor activity

    Interesting, Mr. Hamster has read in these papers that d-ethylphenidate has about an order of magnitude more affinity for DAT than cocaine. That's a bit of kibble for thought. Some even think it might be a methadone to cocaine, but the hamster thinks it's probably pretty addictive and just as moreish as cocaine.

    The hamster has noticed that combining methylphenidate with alcohol is quite euphoric and moreish as the methylphenidate undergoes transesterfication in the liver much the same way cocaine does to produce cocaethylene.

    A hamster, chinchilla or gerbil would be best advised to treat this one with caution.

    Be well...
     
    Last edited: Jul 8, 2011
  7. Days of Daze

    Days of Daze Newbie

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    Re: Ethylphenidate

    haha SWIM just bought some concertas after reading about ethylphenidate yesterday. SWIM hopes it to be about as euphoric as dexamp because he needs to find a less addictive and neurotoxic substance than amphetamines (SWIM was becoming habituated).
     
  8. machine_elf

    machine_elf Newbie

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    Re: Ethylphenidate

    I apologise if I have read this incorrectly (as I am intensely tired) but from what I can see, this research seems to suggest that l-ethylphenidate is biologically inactive, making the d-Isomer the only viable option for research chemical suppliers and users alike.
    If this is the case it would certainly explain the abscence of effects reported by some swimmers. I must say that I find it curious that the l isomer was chosen by RC suppliers as opposed to the racemate.
     
  9. User-126494

    User-126494 Newbie

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    Re: Ethylphenidate

    Mr. Hamster has re-read both papers and there was some confusion on his part regarding the terminology between the two papers for identifying the isomers. One paper used the d/l designation and the other uses +/-.

    The d(+) isomer is more active by an order of magnitude at dopamine reuptake inhibition than cocaine. It later goes on to state that the increased activity in the + isomer has prompted some manufacturers to formulate isometric versions preferring the d(+) isomer, one of which being Focalin by Novartis.

    The hamster agrees that is is odd that the RC developers would be concentrating their efforts on the l-ethylphenidate isomer since it is relatively inactive, according to the above papers.

    Hopefully that clears that up, and thanks for pointing out the mistake the hamster made by stating l- instead of d- for the active isomer. He's corrected it in the above post.

    Be well...
     
  10. Hands_CleaN

    Hands_CleaN Titanium Member

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    Re: Ethylphenidate

    It seems very strange to me that L-threo-ethylphenidate is being sold on the rc sites, by reading through many experience reports it seems the L isomer happens to be the distomer, just like with methylphenidate....I'm suprised the L isomer has any effect at all, maybe it undergoes epimerization in the body to some extent to give some of the racemate....better off just going with the D isomer or the racemate to start with IMO....
     
  11. a-SalviaLover

    a-SalviaLover Silver Member

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    Re: Ethylphenidate

    From what I can understand by the reviews Ethylphenidate sold by RC providers is crap. is there anyone to disagree with this?
     
  12. twoiko

    twoiko Titanium Member

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    Re: Ethylphenidate

    Not necessarily, though 2 has this to say:
     
  13. a-SalviaLover

    a-SalviaLover Silver Member

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    Re: Ethylphenidate

    SWIM got a sample and tried it. Though not as potent as he'd like it to be. It didn't seem that bad considering the tolerance SWIM has to stimulants.
     
  14. somnitek

    somnitek Silver Member

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    Re: Ethylphenidate

    "Informal results" are back. A warning, of sorts: Another "more-ish" compound, it seems. Potential for cardiovascular trouble probably (stress, probably) lower than with, say, MDAI, MPA, or Dimethieocaine, and like. Still, impulse to re-dose being what it is.

    Alright, so a few other things worth mentioning:

    - It seems to be a popular idea to snort this drug. SWIM personally hates this method. It burns, pretty badly (not the worst, but bad) for one thing. Also, at one point, it caked up SWIM's nostril, and presumably his sinuses, as well. He was blowing Ethylphenidate saturated snot out of his right nostril for... God, two, maybe three, days? He'd recommend some other method.

    - For recreational use, SWIM tried this drug IV, and it does produce a euphoric rush, fairly similar to cocaine (though lacking some other things familiar, such as numb tongue, and nausea). SWIM would definitely advise caution, though. Like coke, the urge to re-dose is high. The come-down is sharp, and ugly. Also, the drug's overall duration is considerably longer than coke, but the high is only (seemingly) slightly longer. Also, SWIM noticed that his heart-rate and blood pressure didn't seem to spike as much, as with coke. However, he did not take any measurements at the time.

    - Just like with coke, high dose, short interval dosing is a profoundly bad idea. SWIM found this out the hard way, though he pretty much knew it was all but guaranteed, and proceeded irregardless (try to avoid copying the behavior, you'll be glad you did). Now, SWIM is very much hesitant to recommend any "drug combinations" knowing how dangerous they generally are, but Ethylphenidate is like coke also in the way that the best way to dose (and stretch out whatever amount you have) is to do one, then leave it be for a few hours (at least). This is (another) hard one to do this with, so having some other drug (that won't interact negatively, or is unlikely to) around might be a decently good idea. I'm reluctant to suggest sedatives, pot, alcohol, opiates, etc. ...However, that's what SWIM knows he would want around to deal with the comedown.

    - Finally, SWIM wanted to note that repeated re-use will produce side-effects very similar to binge use with other stimulant type drugs. Nystagmus, ataxia (peripheral), stimulant psychosis, etc. It's a very uncomfortable drug to binge on.

    - This drug has potential beyond just recreational use. Like it's more popular sibling, Methylphenidate (Ritalin), I think it has potential to do well in the treatment of refractory depression, where other meds have failed. The catch is that the drug, for this use, is best dosed orally. A glass of juice would work.

    That's the bulk of it for now.
     
    Last edited: Dec 6, 2011
  15. Seraph

    Seraph Silver Member

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    Can I IV Racemic Ethylphenidate?

    Can I intravenously inject racemic ethylphenidate? Is it safe to intravenously inject racemic ethylphenidate?
     
  16. somnitek

    somnitek Silver Member

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    Re: Ethylphenidate

    I asked SWIM, he says:

    "Wish I could say one way or the other. The vendor it was received from did not state whether the products was racemic, or if it was composed of one specific stereoisomer. I suppose it could have been a mix, as well (not 50/50, but maybe some other ratio). None the less, injection never brought about any unforeseen issues, but as always, use great caution."
     
  17. hX_

    hX_ Titanium Member

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    If you have the CAS number you can check if it is racemic, d or l. Just google it.

    A mate has got a sample collecting dust in a post office waiting for him, should be able to report back again soon.
     
  18. Mōšéh

    Mōšéh Newbie

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    It should be made clear, the subject/s of this report failed to observe proper safety and weighing procedure.

    The observed person (person-A) took a 1/4th of a teaspoon of dl-ethylphenidate and mixed with 50units water... after watching person-A clear the barrel, a tingling in the injection arm was noted. Euphoria didnt seem that potent but observing another reaction (person-B) at a smaller dose; a good level of euphoria was outwardly noticeable.

    Four injections were observed from observed from person-A in a 24hr period. Doses escalated from 2x~100mg injections (5hrs apart) to 2x 200mg doses (4hrs apart). Person-A commented the first set of 200mg injections had the best effect. Person-B also commented that when their dose was double, the effects were noticeably more euphoric and enjoyable.
     
  19. snapper

    snapper Gold Member

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    The ferrets tried 100 mg ethylphenidate IV followed by another an hour later. No rush and the same effect as oral only faster onset. The ferrets do not think it is worth IVing anything unless there is a rush and this does not have one. Overall ethylphenidate is mostly a functional stimulant and is minimally recreational for the test ferrets unless very high oral doses are taken (ie 300+mg). The nice thing about it is that it does wear off fast allowing user to sleep 6 hours after the last dose. Note the ferrets experimented with all other routes of ingestion first and had a good handle on this stuff's effects. Never IV anything and if you do, get to know the chemical really well first.
     
  20. Gutterballz

    Gutterballz Silver Member

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    Interesting information on the conjoining of those substances. SWIM has taken both together, and to be honest, SWIM always received a nausous, unsettling feeling in the abdominal region. If SWIM is reading this correctly though, Ethylphenidate is a substance resulting from the two being chemically combined via a laboratory, not the ingestion of the two precursors separately, having them mix after ingestion.

    SWIM would definitely try this version, likely assuming the previous negative side effects were caused by the gastrointestinal system being the location of the chemical change, among other things.