My friend asked me this question and I am unable to help him so I have turned to forum for any help i can pass on so a bit about him he is 60 years old and suffers with a great deal of pain. 6 months ago he was up to 310 mg of MST plus Oramorph for breakthrough pain. He had gradually got to this amount working up from 15mg twice a day 5years ago, in the end he had to chew them to get relief. He tells me that over the Last few months he has reduced his MST pills to 150mg + Oramorph So on to the Oxycotin he says that the doctor has prescribed him 2 x 40mg per day and 10mg Oxycodone pills for the breakthrough pain and he says they don’t work at all, he has told this to his doctor and has been told to persevere he has also been told that the oxycotin pills should do beter than the 150mg of MST he was on. I know his doctor and he is a male in his late 50s and can be very moody and is very suspicious of anyone seeking pain relief. anyway back to the problem, on Friday he took 4 of his 40mg oxycotin Pills removed time release coating and crushed them up he says he got a little help from them but not much he would also like a bit of a buzz. So anyway, any help on how to get the best out of his Oxycotin and Oxycodone would be of great help. On his behalf I would like to say thank you for taking time out to read this.