Hi im new here. i would like to better understand how drug interactions work.

Discussion in 'Antipsychotics' started by Chad23, Mar 12, 2019.

  1. Chad23

    Chad23 Newbie

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    Hi I'm chad and I'm new here. I am not very good at understanding how drug interaction work and would like some help understanding. The only medicine I take is olanzapine and it has a really long half life. I'm not sure what that means, but I see there are quite a few interactions with olanzapine and I'm guessing that's not good. My question is how this works. Does that mean I would have to wait 44 to 52 hours before I take something on the interactions list? Or does that mean your just not supposed to take them at the exact same time?


    Chad
     
  2. aemetha

    aemetha Sexy Potato Palladium Member Donating Member

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    The half-life is the time it takes for half of the dose to be metabolized and eliminated. So if you take 10mg of olanzapine with a half-life of 21-54 hours you would have 5mg of that dose still in your system 21-54 hours after taking it. Complete (effectively) metabolism is generally considered 5-7 half-lives.

    Now, half-life doesn't necessarily mean duration of action. There are other factors that go into that equation such as active metabolites. An active metabolite is a substance that also causes an effect which is created when your body metabolizes the first substance. An example of this is codeine. Codeine itself only very weakly acts upon the mu opioid receptor, but it metabolizes in part into morphine, which strongly acts upon the mu opioid receptor.

    Not all interactions are bad, some are actually desirable. In the case of olanzapine its interaction with SSRI antidepressants is beneficial in the treatment of treatment-resistant depression. Other interactions can be potentially harmful, such as co-administration of serotonin agonosts (serotonin syndrome), co-administration of depressants (respiratory failure), or pharmacokinetic interactions (where the effect of one drug on the enzymes that metabolize drugs may lead to higher or lower plasma concentrations of the second drug).

    As to whether you should or shouldn't take something at the same time as olanzapine. I really couldn't give any advice on that without knowing the specifics of what it was you were taking.
     
  3. jazzyj9

    jazzyj9 Titanium Member Donating Member

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    Another thing to consider is why you are taking Olanzapine and what drug you are considering doing. Specifically, stimulants for people with psychotic disorders are usually contraindicated and most people who use stimulants recreationally use large amounts which can cause psychosis more easily in persons with psychotic disorders. Knowing why you take olanzapine and what you plan on taking would be helpful to give you better answers. Furthermore, the use of any really strong drugs by someone with any mental health issue is probably not a good idea.
     
  4. Chad23

    Chad23 Newbie

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    I take half of a 5mg olanzipine at night to help me fall asleep. I dont take it for any mental health issues. My metabolism is destroyed so I want to possibly find a ligand that I can take to hyper start my metabolism in my liver. No matter what I eat or how much exercise I do I keep getting fatter, and fatter and fatter.
     
  5. jazzyj9

    jazzyj9 Titanium Member Donating Member

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    Olanzapine has a reputation for causing massive weight gain and metabolic syndrome. Can you ask your doc to try something else?
     
  6. Chad23

    Chad23 Newbie

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    I have tried seroquel, ambien, belsomra and a few others when I was younger. Olanzipine has worked best so far with no bad night time side effects. My doc said I've already tried the good ones for sleep and she is running our of options.
     
  7. jazzyj9

    jazzyj9 Titanium Member Donating Member

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    If I were in your shoes, I would probably try to be referred for a sleep study and/or to see a specialist who can possibly treat your insomnia. Have you done this already?
     
  8. Chad23

    Chad23 Newbie

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    Yes they diagnosed me with narcolepsy, but I have trouble sleeping at night though.
     
  9. jazzyj9

    jazzyj9 Titanium Member Donating Member

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    You should probably go to your doctor and tell her what the problems are and which ones you find intolerable and ask her for suggestions, and/or see another one for their feedback.