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How can I test if a drug (mephedrone) has been cut with creatine

Discussion in 'Drug testing discussion' started by Synesthesiac, Apr 27, 2010.

  1. Synesthesiac

    Synesthesiac R.I.P.

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    My friend has recently purchased some mephedrone and is highly suspicous that it has been cut with creatine as it is about half the strength of normal mephedrone, does not smell like strong mephedrone but more salty and has a more fine texture than usual. A lot of people have suggested that creatine has been used as a cutting agent.

    If any chemists here know of a simple way to test if the powder contains creatine that would be much appreciated.

    Also if there is anything dangerous or unhealthy about ingesting creatine nasally (I cant think of anything serious) that would also be appreciated.
     
  2. Phenoxide

    Phenoxide Super Moderator Staff Member

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    Creatine has a primary amine so should respond to robadope reagent. Mephedrone has only a secondary amine so should respond to simon's reagent but not robadope. Creatine could possibly be ruled out if there is no response to robadope.

    A good place to start would be to use the range of pill testing reagents (including simon's and robadope) on the sample, and see if all results are consistent with mephedrone, which shadowchaser has already uploaded an excellent example of. Any inconsistencies would be cause for concern. Testing a standard known to be creatine (which I'd assume is reasonaly straightforward to acquire) might also be a good idea.

    That said it could be cut with any number of other things which may not respond to any of these tests. The only way to know conclusively that it (a) contains mephedrone at all, and not something else, and (b) is of high-purity, would be to get it analyzed.
     
    Last edited: Apr 27, 2010
  3. Synesthesiac

    Synesthesiac R.I.P.

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    Brilliant answer thanks. Since swim no longer uses mephedrone he is relying on his friends subjective recollection of the effects which he says is about half the usual potency and is 'not as euphoric' but much more speedy, and he said he was able to eat meals with no problem which I've never seen him do before while using real mephedrone. Swim can however tell just by smelling his bag and dabbing a bit on his tongue that its definately not pure mephedrone. Looks like he's going to need to invest in some more test kits now. I'll post whatever the result is and see if we can identify if it is mephedrone, if it has creatine in, or if not what substance it might be.

    Synesthesiac added 10 Minutes and 18 Seconds later...

    By analyzed I presume you mean by using a GCMS? The one swim used to have access to through his institution now comes with a hefty cost to book it to use so is not really an option. Plus the law regarding mephedrone rather gets in the way of certain conditions needed to use it now. Are there any other ways to test drugs that are more accessible than GCMS and selective ion monitoring techniques?
     
    Last edited: Apr 27, 2010
  4. Phenoxide

    Phenoxide Super Moderator Staff Member

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    Unfortunately not. Assays like simons/robadope treatment are good for testing presence/absence of very specific things, but they are limited by a requirement of prior knowledge as to what the sample might contain. It is also difficult to make reliable deductions from such assays if the sample is a mixture of multiple chemicals. Chemical assays are a useful way to rule out certain chemicals and therefore narrow down the possibilities, but they are never conclusive. The pill testing kits for example cannot distinguish between everything, but are optimized to distinguish between things which are likely to be present in ecstacy pills. They are also not particularly good for purity testing. If the cut is not affected by any testing reagent, then its presence will remain undetected, and SWIY would think they have a pure product.

    The best unsupervised (i.e. no prior knowledge) approaches for purity testing and identification are LC-UV, LC/GC-MS, and NMR. Unfortunately (legal issues aside) these tend to be prohibitively expensive and not particularly accessible services, but they are by far the most reliable ways of conclusively analyzing an unknown sample.
     
  5. bcubed

    bcubed Gold Member

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    Well, Lizard has some experience with using creatine for exercise, and if creatine monohydrate (the kind Lizard's most familiar with) is the suspected adulterant, it's not very soluble in cold water. 6g/L (6mg/ml) @ 4C. He recalls his 1TBSP dose (?gr) basically not dissolving in a glass of water and having to be consumed as a suspension shortly after stirring.

    Lizard also seems to recall taking a snootful of creatine monohydrate (nostalgic for blow) and winding up with a nostril-full of grit!

    If mephedrone is much more soluble in cold water, one could do a CWE and leave the grit behind! (No guarantee the cutting agent is removed, unless the cutting agent is creatine monohydrate.)
     
    Last edited: Apr 28, 2010
  6. Synesthesiac

    Synesthesiac R.I.P.

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    Ok here are the rusults swim has got from his mate using a EZ test kit complete.

    Marquis = Dissolved totally clear
    Simons = Mephedrone dissolved, then buffer was addded and solution turned grey.
    Robadope = Mephedrone dissolved, then buffer was addded and solution turned grey
    Mandelin = Mephedrone dissolved and solution turned slightly yellow after buffer was added.

    Conclusions: Inconclusive, but implies its not pure mephedrone.

    Hmm.
     
    Last edited: May 26, 2010
  7. Seaquake

    Seaquake Gold Member

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    [​IMG]
    [​IMG]

    here's the pics that Phenoxide was talking about.

    Swim's pretty sure swiy are not meant to add buffer to mandelin
     
  8. Synesthesiac

    Synesthesiac R.I.P.

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    Yes swim just realised that after he did it! after retesting it was still a similar end product though.

    Those pictures are very interesting, as there are traces of that blackish color in the simons reagent swim did but they are very sparce and its only wisps of black, but is definately there. Mandalin is the same color as above.

    Swim will re-test tomorrow now he has that guide to go by and use more meph in each test and upload a picture.

    Also swim might dissolve a gram of his friends mephedrone and let it evaporate to see if the end product loses mass. Presumably if its pure mephedrone then no mass should be lost during evaporation?
     
    Last edited: May 27, 2010